Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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外文摘要：Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)rates.This study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a decade.Methods Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live births.Health-related claims data,encompassing diagnostic codes,diagnostic test costs,and adminis-tered procedures were sourced from the NHIS database.The results of the developmental assessments are categorized into four groups based on standard deviation(SD)scores.Neonatal characteristics and complications were compared among the groups.Logistic regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95％confidence intervals for each risk factor associated with mortality and morbid-ity in IVH.Long-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12％in VLBW and 16％in extremely low birth weight(ELBW)infants.Over the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improve-ments in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with IVH.Ten percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ven-triculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over time.The IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P＜0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test results.Conclusions The neurodevelopmental outcomes of infants with IVH,especially those subjected to surgical treatments,continue to be a matter of concern.It is imperative to prioritize specialized care for patients receiving surgical treatments and closely monitor their growth and development after discharge to improve developmental prognosis.

外文关键词：

Cerebral intraventricular hemorrhageDevelopmentalHydrocephalusMortalityPosthemorrhagic ventricular dilatationSurgery

作者：

Joonsik Park、Sook-Hyun Park、Yu-ra Kwon、So Jin Yoon、Joo Hee Lim、Jung Ho Han、Jeong Eun Shin、Ho Seon Eun、Min Soo Park、Soon Min Lee

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作者单位：

Department of Pediatrics,Yonsei University College of Medicine,211 Eonjuro Gangnamgu,Seoul 06273,Republic of Korea

基金：

Korea Medical Device Development Fund grant funded by the Korea government the Ministry of Science and ICTMinistry of Trade,Industry and EnergyMinistry of Health & Welfare,the Ministry of Food and Drug SafetyMinistry of Health & Welfare,the Ministry of Food and Drug Safety

项目编号：

1711138055KMMDF_PR_20200901_0057

出版年：

2024

DOI：

10.1007/s12519-024-00799-x

世界儿科杂志(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.20(7)