Attention deficit hyperactivity disorder in children with epilepsy:a multicenter cross-sectional analysis in China

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外文摘要：Background The diagnosis and treatment of attention deficit hyperactivity disorder(ADHD)comorbid with epilepsy have been insufficiently addressed in China.We conducted a study in China to investigate the current status,diagnosis,and treat-ment of ADHD in children to further our understanding of ADHD comorbid with epilepsy,strengthen its management,and improve patients'quality of life.Methods We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August 2022.We screened all patients for ADHD and compared various demographic and clinical factors between children with and without ADHD,including gender,age,age at epilepsy onset,duration of epilepsy,seizure types,seizure frequency,presence of epileptiform discharges,and treatment status.Our objective was to explore any possible associations between these characteristics and the prevalence of ADHD.Results Overall,395 epilepsy patients aged 6-18 years were enrolled.The age at seizure onset and duration of epilepsy ranged from 0.1-18 to 0.5-15 years,respectively.Focal onset seizures were observed in 212(53.6％)patients,while 293(76.3％)patients had epileptiform interictal electroencephalogram(EEG)abnormalities.Among the 370 patients treated with anti-seizure medications,200(54.1％)had monotherapy.Although 189(47.8％)patients had ADHD,only 31 received treatment for it,with the inattentive subtype being the most common.ADHD was more common in children undergoing polytherapy compared to those on monotherapy.Additionally,poor seizure control and the presence of epileptiform interictal EEG abnormalities may be associated with a higher prevalence of ADHD.Conclusions While the prevalence of ADHD was higher in children with epilepsy than in normal children,the treatment rate was notably low.This highlights the need to give more importance to the diagnosis and treatment of ADHD in children with epilepsy.

外文关键词：

Attention deficit hyperactivity disorderChildrenChinaEpilepsyElectroencephalogram

作者：

Gang Pan、Ying Han、Tian-Cheng Wang、Zi-Yi Chen、Xiang-Qing Wang、Hong-Bin Sun、Yong-Hong Liu、Qun Wang、Wei-Hong Lin、Jin-Mei Li、Shui-Zhen Zhou、Yue-Hua Zhang

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作者单位：

Department of Neurology,Children's Hospital of Fudan University,399 Wan Yuan Road,Minhang District,Shanghai,China

Department of Pediatrics,Peking University First Hospital,Beijing,China

Department of Neurology,Lanzhou University Second Hospital,Lanzhou,China

Department of Neurology,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,China

Department of Neurology,The First Medical Center of Chinese PLA General Hospital,Beijing,China

Department of Neurology,Sichuan Provincial People Hospital,Chengdu,China

Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi'an,China

Department of Neurology,Beijing Tiantan Hospital,Captial Medical University,Beijing,China

Department of Neurology,The First Hospital of Jilin University,Changchun,China

Department of Neurology,Sichuan University West China Hospital,Chengdu,China

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出版年：

2024

DOI：

10.1007/s12519-024-00813-2

世界儿科杂志(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.20(10)