首页|Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts

Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts

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  • 万方数据
  • 维普
Background SARS-CoV-2 continues to mutate over time,and reports on children infected with Omicron BA.5 are limited.We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.Methods We selected 315 consecutively hospitalized children with Omicron BA.5 and 16,744 non-Omicron-infected febrile children visiting the fever clinic at our hospital between December 8 and 30,2022.Specific convulsions and body tempera-tures were compared between the two cohorts.We analyzed potential associations between convulsions and vaccination,and additionally evaluated the brain damage among severe Omicron-infected children.Results Convulsion rates(97.5％vs.4.3％,P＜0.001)and frequencies(median:2.0 vs.1.6,P＜0.001)significantly differed between Omicron-infected and non-Omicron-infected febrile children.The body temperatures of Omicron-infected chil-dren were significantly higher during convulsions than when they were not convulsing and those of non-Omicron-infected febrile children during convulsions(median:39.5 vs.38.2 and 38.6 ℃,both P＜0.001).In the three Omicron-subgroups,the temperature during convulsions was proportional to the percentage of patients and significantly differed(P＜0.001),while not in the three non-Omicron-subgroups(P=0.244).The convulsion frequency was lower in the 55 vaccinated chil-dren compared to the 260 non-vaccinated children(average:1.8 vs.2.1,P＜0.001).The vaccination dose and convulsion frequency in Omicron-infected children were significantly correlated(P＜0.001).Fifteen of the 112 severe Omicron cases had brain damage.Conclusions Omicron-infected children experience higher body temperatures and frequencies during convulsions than those of non-Omicron-infected febrile children.We additionally found evidence of brain damage caused by infection with omicron BA.5.Vaccination and prompt fever reduction may relieve symptoms.

Body temperatureBrain damageChildrenConvulsionOmicron BA.5Vaccination

Yuan-Yuan Pei、Hong-Li Wang、Gen-Quan Yin、Yi Xu、Jian-Hao Tan、Xin-Hua Liang、Hui-Ying Wu、Xun-Tao Yin、Chun-Xiao Fang、Jun-Zheng Peng、Zhi-Yuan Wu、Yi Sun、Run Dang、Yu-Feng Liang、Hong-Mei Tang、You-Yi Li、Zhong-Xiang Qiao、Zhi-Cheng Liang、Jian-Ping Tang、Fan-Sen Zeng、Ke-Lu Zheng、Yi-Ru Zeng、Xiao-Jun Cao、Hui-Min Xia、Jian-Rui Wei、Jin-Ling Tang、Si-Tang Gong

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Clinical Data Center,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Department of Gastroenterology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Department of Internal Medicine,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Department of Infectious Diseases,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Information Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

School of Pediatrics,Guangzhou Medical University,Guangzhou 510623,China

Imaging Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Respiratory Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Pediatric Intensive Care Unit,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Neonatal Intensive Care Unit,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Rehabilitation Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

General Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Emergency Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Department of Neurology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Key Laboratory of Structural Birth Defects Research in Guangdong Province,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Cardiovascular Department,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China

Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

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2024

10.1007/s12519-024-00808-z

世界儿科杂志(英文版)

世界儿科杂志(英文版)

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ISSN：
年,卷(期)：2024.20(10)