首页|Evaluation of antibody responses in healthy individuals receiving SARS-CoV-2 inactivated vaccines

Evaluation of antibody responses in healthy individuals receiving SARS-CoV-2 inactivated vaccines

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Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in China.However,more investigation is still needed to understand antibodies'duration and effec-tiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants in the real world.In this study,575 participants who had been vaccinated with two or three doses of the inactivated vaccine were recruited.Serum samples were collected and tested for anti-spike IgG and neutralizing antibodies against SARS-CoV-2(original strain,Dela,and Omicron).Unsurprisingly,a third dose of the vaccine significantly enhanced antibody responses against SARS-CoV-2 and its variants.However,despite a booster dose,the neu-tralizing antibody levels against Omicron,particularly the BA.5.2 subvariant,remained low.There was no sex bias,but an age bias was observed.Notably,the predominant IgG subclass antibodies were IgG1 and IgG2,with a much lower level of IgG4.After the booster shot,the ratio of IgG4 to IgG1 significantly increased.The obser-vation of IgG1 to the IgG4 class switch after repeated inactivated vaccinations underscores the importance of continuous monitoring of subclass antibody responses.Further clinical investigations are required to under-stand the implications of this class switch for optimizing immunization strategies.

Variant of concern(VOC)Inactivated vaccinesSerological studyIgG subclassesSevere acute respiratory syndrome coronavirus 2(SARS-CoV-2)

Ziyu Liu、Liyan Cai、Man Xing、Nan Qiao、Jiaojiao Liu、Xuejun Li、Chiyu Zhang、Naijun Tang、Zhelong Xu、Yingying Guo、Renfei Lu、Dongming Zhou

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Department of Pathogen Biology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China

Physical examination center,Affiliated Nantong Hospital 3 of Nantong University,Nantong 226000,China

Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China

Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin 300070,China

Clinical Laboratory,Affiliated Nantong Hospital 3 of Nantong University,Nantong 226000,China

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Key Project of the Natural Science Foundation of Tianjin,China

20JCZDJC00090

2024

10.1016/j.bsheal.2024.04.001

生物安全与健康 (英文)
中华医学会

生物安全与健康 (英文)

CSTPCD
ISSN：2096-6962
年,卷(期)：2024.6(3)
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