The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

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外文摘要：Integrase strand transfer inhibitors(INSTIs)have emerged as the first-line choice for treating human immun-odeficiency virus(HIV)infection due to their superior efficacy and safety.However,the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV(PLWH)is not fully understood due to limited data.In this study,we conducted a cross-sectional examination of PLWH receiving antiretroviral therapy,with a specific focus on HIV-positive men who have sex with men(MSM)on INSTI-based regimens(n=61)and efavirenz(EFV)-based regimens(n=28).Participants underwent comprehensive neuropsychi-atric evaluations and multimodal magnetic resonance imaging(MRI)scans,including T1-weighted images and resting-state functional MRI.Compared to the EFV group,the INSTI group exhibited primarily reduced gray matter volume(GMV)in the right superior parietal gyrus,higher regional homogeneity(ReHo)in the left post-central gyrus,lower ReHo in the right orbital part of the inferior frontal gyrus,and increased voxel-wise func-tional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right cuneus.Furthermore,the analysis revealed a main effect of antiretroviral drugs on GMV changes,but no main effect of neuropsychiatric disorders or their interaction.The repeated analysis of participants who did not switch reg-imens confirmed the GMV changes in the INSTI group,validating the initial findings.Our study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI-based regimens compared to those on EFV-based regimens.These neuroimaging results provide valuable insights into the characteristics of brain net-work modifications in PLWH receiving INSTI-based regimens.

外文关键词：

Human immunodeficiency virus(HIV)Multimodal magnetic resonance imaging(MRI)Integrase strand transfer inhibitors(INSTIs)Efavirenz(EFV)

作者：

Yihui He、Yang Zhang、Jiaxin Zhen、Guangqiang Sun、Zhen Li、Bo Yang、Bin Yang、Keyi Chang、Xue Chen、Yulin Zhang、Caiping Guo、Wen Wang、Ping Wu、Tong Zhang、Lei Wang

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作者单位：

Postgraduate Union Training Base of Jinzhou Medical University,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China

Department of Neurology,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China

Center for Infectious Disease,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China

Beijing Key Laboratory for HIV/AIDS Research,Beijing 100069,China

Beijing Institute for Sexually Transmitted Disease Control,Beijing 100069,China

Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders and National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China

Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China

The Second Hospital of Beijing,Beijing 100031,China

Department of Respiratory and Critical Care Medicine,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence,Peking University,Beijing 100191,China

Key Discipline for Neuroscience of the Ministry of Education,Department of Neurobiology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaBeijing Natural Science FoundationBeijing Natural Science FoundationPeak Talent Program of Beijing Hospital AuthorityCapital's Funds for Health Improvement and ResearchResearch and Translational Application of Clinical Characteristic Diagnostic and Treatment Techniques in Capital CityBeijing Research Center for Respiratory Infectious DiseasesBeijing Hospitals Authority Innovation Studio of Young Staff Funding SupportHighlevel Public Health Technical Personnel Construction ProjectHighlevel Public Health Specialized Talents Project of Beijing Municipal Health commissionBeijing Key Laboratory for HIV/AIDS Research

项目编号：

8207227182241072820722942021YFC25014022021YFC012260172220957222091DFL201917012022-1-1151Z221100007422055BJRID2024-00120210372022-1-0072022-02-20BZ0089

出版年：

2024

DOI：

10.1016/j.bsheal.2024.07.001

生物安全与健康 (英文)

中华医学会

生物安全与健康 (英文)

CSTPCD

ISSN：2096-6962

年,卷(期)：2024.6(4)