首页|A secure visualization platform for pathogenic genome analysis with an accurate reference database

A secure visualization platform for pathogenic genome analysis with an accurate reference database

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  • NETL
  • NSTL
  • 万方数据
Investigating the genetic and developmental characteristics,infection transmission attributes,and epidemio-logical trends of pathogens using genomic data represents the foundation for pathogen surveillance and is a crucial prerequisite for guaranteeing global health security.To meet the analytical demands of research relat-ing to pathogen prevention and control,we designed a secure visualization system capable of pathogen genome assembly,annotation,species identification,sequence typing,antibiotic resistance and virulence analysis,genomic mobile element and transferable resistance gene annotation,and phylogenetic tree reconstruction.For highly pathogenic organisms requiring complete data protection,we have developed a secure computing tool that utilizes a trusted execution environment,is combined with blockchain and privacy computing tech-nologies,and is specifically designed for nucleotide basic local alignment search tool(BLASTn)comparison analysis.This technological advancement offers scientific support for in-depth investigations into pathogen transmission and epidemiological mechanisms,environmental adaptability,evolutionary trends,and immune evasion mechanisms,as well as the identification of new or emerging pathogen strains.This,in turn,aids efforts in infectious disease prevention,treatment,and research.

Pathogen surveillanceOne-stop analysis toolsSequence typingHorizontal transferSecure computing

Guomei Fan、Chongye Guo、Qian Zhang、Dongmei Liu、Qinglan Sun、Zhigang Cui、Haijian Zhou、Yuanchun Zhou、Zhibin Guo、Juncai Ma、Linhuan Wu

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Microbial Resource and Big Data Center,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

Chinese National Microbiology Data Center(NMDC),Beijing 100101,China

National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China

Computer Network Information Center,Chinese Academy of Sciences,Beijing 100190,China

State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

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National Key Research and Development Program of China,China

2021YFC2300900

2024

10.1016/j.bsheal.2024.07.003

生物安全与健康 (英文)
中华医学会

生物安全与健康 (英文)

CSTPCD
ISSN：2096-6962
年,卷(期)：2024.6(4)