MiRNAs are ~22-nucleotide-long endogenously expressed non-coding single-strain KNAs that regulate the gene transcription. They could modulate the growth, development and diseases of organism by inhibition of post-transcriptional translation and degradation of mRNA, through binding its 5' UTR to 3'UTR of mRNA. It has been proposed that miRNAs play a significant role in differentiation of stem cells, formation of cancer, angiogenesis, development of inner ear, and so on, which has been a core factor of regulation of biological processes. Cutaneous wound healing is a complex biologic process involved in several type of cells, cytokines and extracellular matrix, which is strictly regulated by lots of factors. It has been divided into 3 phases: inflammation, granulation proliferation and tissue reconstruction. A large number of evidence suggested that miRNAs play a significant role in this process, and specific miRNAs are expressed in specific phases. This article reviews the role of miRNA in skin morphogenesis, fetal scarless healing and different stage of adult wound repair.
NETL
NSTL
万方数据
维普
