肺磨玻璃结节中ki-67的表达及与P53,EGFR,CEA相关性研究
The Expression ofki-67 in Ground-glass Opacity (GGO) and its Relation with P53, EGFR, CEA
彭明政 1彭菲 2李钊 1周建华 1林强1
作者信息
- 1. 上海交通大学附属第一人民医院胸外科 上海200080
- 2. 湖南师范大学医学院附属湖南省人民医院 湖南长沙410006
- 折叠
摘要
目的:为探究不同病理类型的肺磨玻璃结节(ground-glass opacity,GGO)中ki-67的表达情况及其与肺癌相关标志物p53、p63、EGFR等表达的相关性.方法:收集从2012年10月至2014年10月我院胸外科收治的254例GGO病人的临床病史、影像、病理及血常规等资料予以回顾性分析.结果:Ki-67表达量从良性组(n=66),不典型腺瘤样增生(atypical adenomatous hyperplasia,AAH,n=27),到原位癌(adenocarcinoma in situ,AIS,n=11),微浸润腺癌(minimally invasive adenocarcinoma,MIA,n=108),最后到浸润性腺癌(invasive adenocarcinoma,IAC,n=42)即随着早期肺癌的演进过程不断增高.Ki-67与各标志物的相关系数为0.386(p53,P＜0.001)、0.227(EGFR,P=0.024)、0.441 (CEA,P＜0.001).通过ROC曲线分析得到ki-67来判别良恶性GGO的曲线下面积和最佳阈值,也得到了早期肺癌演进过程中ki-67阈值变化.恶性GGO组全血细胞中平均单核细胞含量低于良性组GGO,且差异有统计学意义.结论:ki-67表达量在不同病理类别的GGO中有显著性差异,且在肺癌演进过程中依次增高,可作为鉴别早期肺癌不同病理类型的参考依据和预后因子;ki-67与P53、EGFR及CEA的表达具有一定的相关性.
Abstract
Objective:To explore the expression of ki-67 in the GGO of different pathology and try to find whether the correlation ofki-67 with P53,EGFR and CEA.Methods:The clinical history,CT information,white blood cell count and pathology material of 254 cases with GGO during 2012 and 2014 were collected and analyzed retrospectively.Results:The expression level ofki-67 was gradually increased from Benign group (n=66),AAH (n=27),AIS (n=11),MIA (n=108),to IAC (n=42),which is exactly the evolution progression of early lung adenocarcinoma;The correlation coefficient were 0.386 (p53,P＜0.001),0.227(EGFR,P=0.024) and 0.441 (CEA,P＜0.001) respectively;By ROC curve analysis,we got the AUC and optimal cut-off points of ki-67 with regarding to differentiation of GGO and the variation of thresholds along the progression of early lung adenocarcinoma;The number and the percentage of blood monocyte of the patients with malignant GGO were lower than these of benign group.Conclusions:There are significant differences among GGOs of different pathologic categories with respect to the expression of ki-67 that gradually increased in the early lung adenocarcinoma progression.To some extent,a positive correlation ofki-67 with P53,EGFR and CEA exists.
关键词
肺磨玻璃结节/GGO/ki-67/p53/ROCKey words
Ground-glass opacity/ki-67/Correlation/p53/ROC引用本文复制引用
出版年
2015
NETL
NSTL
维普
万方数据