Effect of Repaglinide Combined with Metformin on the PAI-1 Levels of Type 2 Diabetic Patients' in Xining Area
Objective:To investigate the clinical effect of repaglinide combined with mefformin on the PAI-1 levels of type 2 diabetic patients in Xining area.Methods:98 cases of patients with type 2 diabetes admitted in our hospital from January 2012 to September 2015 were selected and divided into three groups,which were treated with repaglinide,metformin,and both drugs.The fasting blood glucose,glycosylated hemoglobin and PAI-1 levels were detected.Results:The effective rate of combination group was 94.12％,which was significantly higher than the repaglinide group(71.87％) and metformin group (75.00％) (P＜0.05).After treatment,the FBG,HBAlc and PAI-1 levels of three groups were significantly decreased (P＜0.05),which were significantly lower in the combination group than those of repaglinide group and metformin group (P＜0.05) No obvious difference was found in the incidence of hypoglycemia and gastrointestinal among three groups.Conclusion:Compared with single drug treatment,repaglinide combined with metformin could more effectively reduce the PAI-1 levels of patients with type 2 diabetes,which might contribute to the improvement of blood coagulation,decrease of vascular complications,and had no obvious adverse reactions.
NETL
NSTL
万方数据
维普
