首页|缬沙坦联合肾炎康复片治疗女性肾小球肾炎蛋白尿的疗效观察

缬沙坦联合肾炎康复片治疗女性肾小球肾炎蛋白尿的疗效观察

Clinical Curative Effect of Valsartan Combined with Shenyankangfu Tablet in Female Glomerulonephritis Patients

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目的:探讨缬沙坦联合肾炎康复片对女性肾小球肾炎蛋白尿患者的临床疗效和意义.方法:选取2014年1月至2015年12月于本院以肾小球肾炎为诊断的女性患者72例,行随机数字表法分为两组:对照组36例,予缬沙坦治疗;实验组36例,予缬沙坦联合肾炎康复片治疗.共治疗12周.观察两组患者治疗前后血压、24 h尿蛋白、血清Scr、BUN、Hb以及不良反应发生率,其数据结果应用统计学软件SPSS 19.0加以处理.结果:经12周治疗后,实验组临床疗效明显优于对照组,表现为:实验组收缩压、舒张压以及24 h尿蛋白定量水平均低于对照组(P<0.05);实验组血清Scr和BUN水平低于对照组,Hb水平均高于对照组(P<0.05);实验组总有效率高于对照组(P<0.05);两组之间不良反应发生率无统计学意义(P>0.05).结论:缬沙坦联合肾炎康复片能有效降低女性肾小球肾炎蛋白尿患者血压、24 h尿蛋白、血清Scr、BUN水平,升高Hb水平,且具有较好的临床疗效和安全性,值得临床应用和推广.
Objective:To investigate the clinical curative effect of valsartan combined with Shenyankangfu tablet in female glomerulonephritis patients.Methods:72 female glomerulonephritis patients in our hospital from January 2014 to December 2015 were selected and randomly divided into the control group and experiment group,36 cases each group.The patients in control group were treated with Valsartan and the patients in experiment group were given valsartan combined with Shenyankangfu tablet.The blood pressure,24 h urinary protein,serum Scr,BUN,Hb,and the incidence of adverse reactions were compared before and after treatment.Results:After 12 weeks of treatment,compared with the control group,the 1 uantitative levels of systolic blood pressure,diastolic blood pressure and 24 h urinary protein were lower in experiment group (P <0.05),and the serum Scr and BUN levels were lower in experiment group (P<0.05),but the Hb level was higher (P<0.05),the effective rate was higher in the experiment group (P<0.05).Conclusions:Valsartan combined with Shenyankangfu tablet has good clinical efficacy and safety in female patients with glomerulonephritis and proteinuria,it can effectively reduce blood pressure and urine protein,decrease SCR and BUN level and elevate Hb level,worthy of clinical application and promotion.

ValsartanShenyankangfu TabletGlomerular nephritisProteinuria

李治成、刘芳、张芮、郭睿坤、李丽

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四川大学华西医院肾内科 四川成都610041

西南医科大学附属医院肾内科 四川泸州646000

缬沙坦 肾炎康复片 肾小球肾炎 蛋白尿

四川省自然科学基金

120808H149

2016

现代生物医学进展
黑龙江省森工总医院 哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD
影响因子:0.755
ISSN:1673-6273
年,卷(期):2016.16(34)
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