Influence of Insulin Combined with Alendronate Sodium on the Bone Metabolism in Treatment of Patients with Type 2 Diabetes Mellitus Osteoporosis
Objective:To study influence of insulin combined with alendronate sodium on the bone metabolism in treatment of patients with type 2 diabetes mellitus (T2DM)osteoporosis.Methods:208 patients with T2DM osteoporosis in hospital were enrolled in this study from January 2010 to July 2015.Patients were divided into single insulin group (control group 1),single metformin group(control group 2),metformin combined Alendronate Sodium group (control group 3),and insulin combined Alendronate Sodium group(combined group)according to the random number table method,with 52 cases in each group,they were were given corresponding treatment measures on the basis of conventional calcium,compared bone metabolism related indicators before and after treatment,as well as the adverse reactions during treatment in two groups.Results:Compared in the groups with bone specific alkaline phosphatase (BAP),bone density (BMD)and osteocalcin(BGP)of combined group were significantly higher than before treatment,and tartrate resistant acid phosphatase 5b (TRAP-5b)were significantly lower than before treatment,the differences were statistically significant (P＜0.05);While the BMD,BAP,TRAP-5b and BGP in other three groups before and after treatment had no significant difference (P＞0.05).Compared between groups with the BMD,BAP and BGP in the combined group were significantly higher than those in the other three groups,the TRAP-5b was significantly lower than the other three groups,the differences were statistically significant (P＜0.05).The incidence rate of adverse reaction in four groups had no significant difference (P＞0.05).Conclusion:Using insulin combined alendronate sodium in the treatment of T2DM osteoporosis patients,with good effect,and can also effectively improve the level of bone metabolism,it is worth to be promoted in clinic.
NETL
NSTL
万方数据
维普
