Study on the Diagnostic and Prognostic Evaluation Value of Serum sTREM-1,sTNFR-Ⅱ Combined with CF-6 in Neonatal Early-Onset Sepsis
Objective:To investigate the diagnostic and prognostic evaluation value of serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1),soluble tumor necrosis factor receptor-Ⅱ(sTNFR-Ⅱ)combined with coupling factor-6(CF-6)in neonatal early-onset sepsis(EOS).Methods:170 EOS children who were admitted to Shanghai Children's Hospital from January 2021 to January 2023 were selected as EOS group,patients were divided into poor prognosis group and good prognosis group according to the prognosis outcome,and 100 healthy newborns without infection symptoms in our hospital during the same period were selected as control group.The levels of serum sTREM-1,sTNFR-Ⅱ and CF-6 were detected by enzyme-linked immunosorbent assay.The influencing factors of poor prognosis of neonatal EOS were analyzed by multivariate Logistic regression model,the diagnostic value and poor prognosis evalu-ation value of serum sTREM-1,sTNFR-Ⅱ and CF-6 levels in neonatal EOS were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with control group,the levels of serum sTREM-1,sTNFR-Ⅱ and CF-6 in EOS group were increased(P＜0.05).The incidence of poor prognosis in 170 EOS children was 29.41％(50/170).Multivariate Logistic regression model analysis showed that,birth weight≥2.5 kg and platelet count increased were independent protective factors for poor prognosis of neonatal EOS,premature rupture of membranes and sTREM-1 increased,sTNFR-Ⅱ increased and CF-6 increased were independent risk factors(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of serum sTREM-1,sTNFR-Ⅱ combined with CF-6 in the diagnosis of neonatal EOS was 0.943,which was greater than 0.802,0.821 and 0.816 of sTREM-1,sTNFR-Ⅱ and CF-6 alone.The AUC of serum sTREM-1,sTNFR-Ⅱ combined with CF-6 in evaluating the prognosis of neonatal EOS was 0.928,which was greater than 0.774,0.785 and 0.779 evaluated by sTREM-1,sTNFR-Ⅱ and CF-6 alone.Conclusion:The levels of serum sTREM-1,sTNFR-Ⅱ and CF-6 were in-creased in neonatal EOS,which were closely relate to poor prognosis,the diagnostic value and poor prognosis evaluation value of serum sTREM-1,sTNFR-Ⅱ combined with CF-6 in neonatal EOS were higher.
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