Evaluation Value of Serum GP73,hs-CRP Combined with APRI in Evaluating Liver Fibrosis and Antiviral Therapy Response in Patients with Chronic Hepatitis B
Objective:To investigate the evaluation value of serum Golgi protein 73(GP73),high-sensitivity C-reactive protein(hs-CRP)and aspartate aminotransferase/platelet ratio index(APRI)in evaluating liver fibrosis and antiviral therapy response in patients with chronic hepatitis B(CHB).Methods:The 187 newly diagnosed CHB patients admitted to our hospital from January 2019 to January 2022 were selected as the research subjects.Based on liver biopsy results,they were divided into a non fibrosis group of 41 cases,a fibro-sis S1 stage group of 43 cases,a fibrosis S2 stage group of 39 cases,a fibrosis S3 stage group of 36 cases,and a fibrosis S4 stage group of 28 cases;Patients with liver fibrosis ≥ S2 stage were treated with antiviral therapy and were divided into a response group(n=76)and a non-response group(n=27)based on the treatment response.The serum GP73,hs-CRP and APRI before treatment were compared be-tween different liver fibrosis groups and different efficacy groups,the predictive value of serum GP73,hs-CRP combined with APRI for non-response to antiviral treatment of CHB were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum GP73,hs-CRP and APRI fibrosis S4 group were higher than those in fibrosis S3 group,fibrosis S3 group was higher than that in fibrosis S2 group,fibrosis S2 group was higher than that in fibrosis S1 group,fibrosis S1 group was higher than that in non-fibrosis group,non-re-sponse group was higher than that in response group,and the differences were statistically significant(P＜0.05).The area under the curve(AUC)of serum GP73,hs-CRP,APRI and combined prediction of non-response to antiviral therapy for CHB were 0.803,0.731,0.785 and 0.903 respectively,the prediction accuracy of combined detection was higher than that of each index alone.Conclusion:Serum GP73,hs-CRP and APRI are relate to the degree of liver fibrosis and the response to antiviral therapy in CHB patients,combine detection has a high predictive value for non-response to antiviral therapy in patients with CHB fibrosis.
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