摘要
目的:探讨慢性牙周炎伴咬合创伤患者龈沟液骨硬化蛋白(Sclerostin)、神经轴突导向因子3(SLIT3)与牙周临床指标和核因子-Kb受体活化因子配体(RANKL)-骨保护蛋白(OPG)系统的相关性.方法:选择2021年1月至2023年1月我院收治的123例慢性牙周炎伴咬合创伤患者(创伤组)和101例不伴咬合创伤的慢性牙周炎患者(对照组).治疗前,检测龈沟液中Sclerostin、SLIT3、RANKL、OPG水平,计算RANKL/OPG比值,评估临床牙周指标出血指数(SBI)、菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL).分析Sclerostin、SLIT3与牙周临床指标、RANKL、OPG、RANKL/OPG之间的相关性.结果:创伤组治疗前龈沟液中Sclerostin、SLIT3、RANKL 水平,RANKL/OPG,PLI、SBI、AL、PD 高于对照组(P＜0.05),OPG 低于对照组(P＜0.05).创伤组治疗前龈沟液中 Sclerostin、SLIT3 与 PLI、SBI、AL、PD、RANKL、RANKL/OPG 呈正相关(P＜0.05),与 OPG 呈负相关(P＜0.05).结论:慢性牙周炎伴咬合创伤患者龈沟液中Sclerostin、SLIT3水平显著增高,且与牙周临床指标异常、RANKUOPG增加有关.
Abstract
Objective:To investigate the correlation of sclerostin and nerve axon guidance factor 3(SLIT3)in gingival crevicular fluid with periodontal clinical indicators and nuclear factor-Kb receptor activator ligand(RANKL)-osteoprotegerin(OPG)system in pa-tients with chronic periodontitis and occlusal trauma.Methods:123 patients with chronic periodontitis and occlusal trauma(trauma group)and 101 patients with chronic periodontitis without occlusal trauma(control group)who were admitted to our hospital from Jan-uary 2021 to January 2023 were selected.Before treatment,the levels of Sclerostin,SLIT3,RANKL and OPG in gingival crevicular fluid were detected,the ratio of RANKL/OPG was calculated,and the clinical periodontal indexes such as bleeding index(SBI),plaque index(PLI),probing depth(PD)and attachment loss(AL)were evaluated.The correlation between Sclerostin,SLIT3 and periodontal clinical indicators,RANKL,OPG,RANKL/OPG was analyzed.Results:The levels of Sclerostin,SLIT3,RANKL,RANKL/OPG,PLI,SBI,AL and PD in gingival crevicular fluid in trauma group before treatment were higher than those in control group(P＜0.05),and OPG was lower than that in control group(P＜0.05).Sclerostin and SLIT3 in gingival crevicular fluid in trauma group were positively correlated with PLI,SBI,AL,PD,RANKL and RANKUOPG ratio before treatment(P＜0.05),and negatively correlated with OPG(P＜0.05).Conclusion:The levels of Sclerostin and SLIT3 in gingival crevicular fluid of patients with chronic periodontitis and occlusal trauma are significantly in-crease,which is relate to the abnormal periodontal clinical indicators and the increase of RANKL/OPG.
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