Study on the Correlation of Sclerostin and SLIT3 in Gingival Crevicular Fluid with Periodontal Clinical Indicators and RANKL-OPG System in Patients with Chronic Periodontitis and Occlusal Trauma
Objective:To investigate the correlation of sclerostin and nerve axon guidance factor 3(SLIT3)in gingival crevicular fluid with periodontal clinical indicators and nuclear factor-Kb receptor activator ligand(RANKL)-osteoprotegerin(OPG)system in pa-tients with chronic periodontitis and occlusal trauma.Methods:123 patients with chronic periodontitis and occlusal trauma(trauma group)and 101 patients with chronic periodontitis without occlusal trauma(control group)who were admitted to our hospital from Jan-uary 2021 to January 2023 were selected.Before treatment,the levels of Sclerostin,SLIT3,RANKL and OPG in gingival crevicular fluid were detected,the ratio of RANKL/OPG was calculated,and the clinical periodontal indexes such as bleeding index(SBI),plaque index(PLI),probing depth(PD)and attachment loss(AL)were evaluated.The correlation between Sclerostin,SLIT3 and periodontal clinical indicators,RANKL,OPG,RANKL/OPG was analyzed.Results:The levels of Sclerostin,SLIT3,RANKL,RANKL/OPG,PLI,SBI,AL and PD in gingival crevicular fluid in trauma group before treatment were higher than those in control group(P＜0.05),and OPG was lower than that in control group(P＜0.05).Sclerostin and SLIT3 in gingival crevicular fluid in trauma group were positively correlated with PLI,SBI,AL,PD,RANKL and RANKUOPG ratio before treatment(P＜0.05),and negatively correlated with OPG(P＜0.05).Conclusion:The levels of Sclerostin and SLIT3 in gingival crevicular fluid of patients with chronic periodontitis and occlusal trauma are significantly in-crease,which is relate to the abnormal periodontal clinical indicators and the increase of RANKL/OPG.
Chronic periodontitisOcclusal traumaGingival crevicular fluidSclerostinSLIT3Periodontal clinical indicatorsRANKL-OPG system
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