Clinical Study of Metformin Combined with Exercise Therapy in Intervention of Patients with Gestational Diabetes Mellitus
Objective:To explore the influence of metformin combined with exercise therapy on the clinical effect of patients with gestational diabetes mellitus(GDM).Methods:89 patients with gestational diabetes admitted to Beijing Aerospace General Hospital from March 2020 to March 2022 were were randomly divided into observation group(n=45)and control group(n=44)according to the coin toss method.The control group was given metformin hydrochloride tablets orally,while the observation group was given exercise therapy on the basis of the control group.The clinical efficacy,blood glucose indicators,oxidative stress indicators,inflammatory factor levels,pregnancy outcomes,and adverse reactions of the two groups of patients were compared.Results:After treatment,After treatment,the total effective rate of clinical efficacy in the observation group was 93.33％(42/45),which was higher than 75.00％(33/44)in the control group(P＜0.05).After treatment,fasting blood glucose(FPG),2 h plasma glucose(2hPG),and glycosylated hemoglobin(HbAlc)in both groups decreased,and the observation group was significantly lower than the control group(all P＜0.05).After treatment,the levels of superoxide dismutase(SOD)in both groups increased and the observation group was significantly higher than the control group,while the levels of malondialdehyde(MDA)and reactive oxygen species(ROS)decreased and the observation group was significantly lower than the control group(all P＜0.05).After treatment,the level of hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α),interleukin-6(IL-6)in both groups decreased and the observation group was significantly lower than that in the control group(all P＜0.05).The incidence of cesarean section and premature delivery in the observation group was lower than that in the control group(all P＜0.05).There was no difference in the total incidence of adverse events between the two groups during treatment(P＞0.05).Conclusion:Metformin combined with exercise therapy can effectively control blood glucose levels in GDM patients,optimize oxidative stress indica-tors,reduce inflammatory factor levels,and improve pregnancy outcomes,and has certain safety.
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