Correlation Analysis of Serum S100A2,S100A12 and Inflammatory Factors in Active Ulcerative Colitis and Their Predictive Value for Recurrence
Objective:To investigate the correlation analysis of serum S100 calcium-binding protein(S100)A2 and S100A12 and inflammatory factors in active ulcerative colitis(UC)and their predictive value for recurrence.Methods:102 active UC patients who were admitted to our hospital from January 2019 to January 2021 were selected as active stage group,patients were divided into recur-rence group and non-recurrence group according to whether recurrence after 2 year,another 50 remission stage UC patients who came to the hospital for follow-up during the same period were selected as remission stage group,50 healthy individuals undergoing physical examination were selected as control group.The levels of serum S100A2,S100A12 and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were detected and compared among three groups.The correlation between serum S100A2,S100A12 and inflammatory factors in active UC patients were analyzed by Pearson/Spearman correlation,the influencing fac-tors of recurrence of active UC were analyzed by univariate and multivariate Logistic regression analysis,the predictive value of serum S100A2 and S100A12 levels on the recurrence of active UC were analyzed by receiver operating characteristic curve.Results:The levels of serum S100A2,S100A12,CRP,IL-6 and TNF-α in control group,remission stage group and active stage group increased in turn(P＜0.05).The serum levels of S100A2 and S100A12 in active UC patients were positively correlated with the levels of CRP,IL-6 and TNF-α(all P＜0.001).Follow up for 2 year,the recurrence rate of 102 active UC patients was 56.86％(58/102).Single factor analysis shows that,the severity of disease,CRP,IL-6,TNF-α,S100A2 and S100A12 were the influencing factors of recurrence in active UC patients(P＜0.05).Multivariate Logistic regression analysis showed that,the severity of the disease was severe and the increase of CRP,IL-6,TNF-α,S100A2 and S100A12 were independent risk factors of recurrence in active UC patients(P＜0.05).The areas under the curve of serum S100 A2 and S100 A12 levels alone and in combination for predicting the recurrence of active UC were 0.782,0.784 and 0.876 respec-tively,the predictive value of the combination of the two indicators in predicting the recurrence of active UC patients was greater than that of each indicator alone.Conclusion:Serum S100 A2 and S100 A12 are closely relate to the levels of inflammatory factors and recur-rence active UC patients,and combination of serum S100A2 and S100A12 has a high value in predicting the recurrence of active UC patients.
Ulcerative colitisS100 calcium-binding protein A2S100 calcium-binding protein A12InflammationRecurrencePrediction
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