Correlation Study between Vitamin D Deficiency and Risk of Retinopathy in Type 2 Diabetes
Objective:To explore the relationship between vitamin D deficiency and the risk of Diabetic retinopathy(DR)in pa-tients with Type 2 diabetes mellitus(T2DM).Methods:Patients with type 2 diabetes mellitus who were hospitalized in the Endocrinology Department of the Second Affiliated Hospital of Xinjiang Medical University from December 2020 to August 2022 were selected as the research objects.According to fundus examination,209 patients were divided into DR Group(n=50)and non-diabetic retinopathy(NDR)group(n=1 59).The general data and laboratory examination indexes of patients in each group were compared.Spearman analysis was used to analyze the correlation between the duration of disease,FBG,HbAlC,25(OH)D and DR.Pearson analysis was used to analyze the correlation between residence(town),vitamin D deficiency,SBP and DR.logistics regression was used to analyze the influencing factors of DR.The predictive value of vitamin D deficiency,disease duration,FBG,HbAlC and 25(OH)D for DR Were compared among the groups.Results:The residence(rural),FBG,HbAlC,and course of disease in the DR Group were higher than those in the NDR group,the 25(OH)D level was lower than that in the NDR group,and the vitamin D deficiency rate in the DR Group was higher than that in the NDR group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that DR Was negatively correlated with residence(town)(P＜0.05),and positively correlated with SBP and vitamin D deficiency(P＜0.05).Spearman correlation analysis showed that DR Was negatively correlated with 25(OH)D(P＜0.05),and positively correlated with course of disease,fasting blood glucose and glycosylated hemoglobin(P＜0.05).Logistic regression analysis showed that vitamin D deficiency,course of disease,FBG and HbAlC were independent risk factors for DR(P＜0.05).The risk of DR In T2DM patients with vitamin D deficiency was 22.019 times higher than that in patients without vitamin D deficiency(OR=22.019,95％CI 2.119-228.771,P＜0.05).Receiver operating charac-teristic(ROC)curve analysis showed that the duration of diabetes,FBG,HbAlC and 25(OH)D as combined variables could effectively predict DR,and the area under the ROC curve was 0.924.Conclusions:25(OH)D is negatively correlated with DR,and vitamin D defi-ciency may be related to the occurrence of DR In T2DM patients.
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