Relationship between Serum ANXA1,dickkopf-1 and the Degree of Brain Injury and Prognosis in Patients with Aneurysmal Subarachnoid Hemorrhage
Objective:To investigate the relationship between serum Annexin AI(ANXA1),dickkopf related proteins-1(dick-kopf-1)levels and the degree of brain injury and prognosis in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods:100 patients with aSAH admitted to The 901 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army from Nov 2018 to May 2021 were selected as the observation group,and 101 healthy physical examination were selected as the control group during the same period.The serum ANXA1,dickkopf-1 levels of two groups were detected,and the differences in serum ANXA1,dickkopf-1 levels between the two groups were compared.The relationship between serum ANXA1,dickkopf-1 levels and the degree of brain injury and the prognosis after surgical treatment in patients with aSAH were analyzed.Results:The level of serum ANXA1 in the observation group was lower than that in the control group(P＜0.05),while the dickkopf-1 level wsa higher than that in the control group(P＜0.05).Spear-man correlation analysis showed that,serum ANXA1 was negatively correlated with Hunt-Hess score,WFNS score and Modified Fisher score(P＜0.05);Serum dickkopf-1 was positively correlated with Hunt-Hess score,WFNS score and Modified Fisher score(P＜0.05).All patients were followed up for half a year,there were 56 patients with poor prognosis after surgery according to statistics,and the inci-dence of poor prognosis was 56％.Multivariate logistic regression analysis showed that,high ANXA1 level was protective factor for poor prognosis in patients with aSAH(P＜0.05);high Dickkopf-1 level,high Hunt-Hess score,high WFNS score,high Modified Fisher score were risk factors for poor prognosis in patients with aSAH(P＜0.05).ROC curve analysis showed that,the combination of serum ANXA1,Dickkopf-1 and Hunt-Hess score,WFNS score,and Modified Fisher score had the highest prognostic value in patients with aSAH,ROC-AUC(0.95CI)was 0.843(0.748～0.942).Conclusions:The levels of serum ANXA1 and dickkopf-1 in patients with aSAH were closely related to the degree of brain injury,and were influence factors for poor prognosis in patients with aSAH.The combination of serum ANXA1,dickkopf-1 with disease score had high evaluation value for the prognosis of patients with aSAH.
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