益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响
Effects of Yixinshu Tablets Combined with Metoprolol on Cardiac Function,Hemorheology and Vascular Endothelial Function in Patients with Angina Pectoris of Coronary Heart Disease
王婷 1程秋雁 1张俐可欣 1胡楠 2黄海涛1
作者信息
- 1. 南京市中心医院药学部 江苏南京 210000
- 2. 常州市第一人民医院药学部 江苏常州 213000
- 折叠
摘要
目的:探讨益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响.方法:纳入南京市中心医院2020年7月～2022年8月期间收治的冠心病心绞痛患者126例.采用随机数字表法分为对照组(n=63,接受美托洛尔治疗)和研究组(n=63,对照组基础上接受益心舒片治疗).对比两组临床症状、心功能[左心室射血分数(LVEF)、心输出量(CO)、左室舒张末期内径(LVEDD)]、血液流变学[血浆黏度、全血高切黏度、全血低切黏度]和血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)]变化情况,同时观察两组不良反应发生率.结果:两组治疗12周后心绞痛发作次数减少,心绞痛持续时间缩短,研究组的改善幅度大于对照组(P＜0.05).两组治疗12周后CO、LVEF升高,LVEDD缩小,研究组的改善幅度大于对照组(P＜0.05).两组治疗12周后血浆黏度、全血高切黏度、全血低切黏度下降,研究组的改善幅度大于对照组(P＜0.05).两组治疗12周后ET-1下降,NO升高,研究组的改善幅度大于对照组(P＜0.05).对照组(4.76％)、研究组(6.35％)的不良反应发生率组间对比未见差异(P＞0.05).结论:益心舒片联合美托洛尔治疗冠心病心绞痛患者,可有效改善患者的血液流变学、心功能和血管内皮功能.
Abstract
Objective:To investigate the effects of yixinshu tablets combined with metoprolol on cardiac function,hemorheology and vascular endothelial function in patients with angina pectoris of coronary heart disease.Methods:126 patients with angina pectoris of coronary heart disease who were admitted to Nanjing Central Hospital from July 2020 to August 2022 were included.Patients were di-vided into control group(n=63,treated with metoprolol)and study group(n=63,treated with yixinshu tablets on the basis of control group)by random number table method.The changes of clinical symptoms,cardiac function[left ventricular ejection fraction(LVEF),cardiac output(CO),left ventricular end diastolic diameter(LVEDD)],hemorheology[plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity]and vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1)]were compared between two groups,and the incidence of adverse reactions in two groups were observed.Results:12 weeks after treatment,the number of angina pec-toris attacks decreased and the duration of angina pectoris shortened in two groups,the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,CO and LVEF increased and LVEDD decreased in two groups,and the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,the plasma viscosity,whole blood high shear vis-cosity and whole blood low shear viscosity in two groups decreased,and the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,ET-1 decreased and NO increased in two groups,and the improvement in study group was greater than that in control group(P＜0.05).There was no difference in the incidence of adverse reactions between control group(4.76％)and study group(6.35％)(P＞0.05).Conclusion:Yixinshu tablets combined with metoprolol can effectively improve the hemorheology,cardiac function,and endothelial function of patients with coronary heart disease and angina pectoris.
关键词
益心舒片/美托洛尔/冠心病心绞痛/心功能/血液流变学/血管内皮功能Key words
Yixinshu tablets/Metoprolol/Angina pectoris of coronary heart disease/Cardiac function/Hemorheology/Vascular en-dothelial function引用本文复制引用
基金项目
江苏省药学会-奥赛康医院药学基金科研项目(A201920)
出版年
2024
NETL
NSTL
万方数据