Effects of Yixinshu Tablets Combined with Metoprolol on Cardiac Function,Hemorheology and Vascular Endothelial Function in Patients with Angina Pectoris of Coronary Heart Disease
Objective:To investigate the effects of yixinshu tablets combined with metoprolol on cardiac function,hemorheology and vascular endothelial function in patients with angina pectoris of coronary heart disease.Methods:126 patients with angina pectoris of coronary heart disease who were admitted to Nanjing Central Hospital from July 2020 to August 2022 were included.Patients were di-vided into control group(n=63,treated with metoprolol)and study group(n=63,treated with yixinshu tablets on the basis of control group)by random number table method.The changes of clinical symptoms,cardiac function[left ventricular ejection fraction(LVEF),cardiac output(CO),left ventricular end diastolic diameter(LVEDD)],hemorheology[plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity]and vascular endothelial function[nitric oxide(NO),endothelin-1(ET-1)]were compared between two groups,and the incidence of adverse reactions in two groups were observed.Results:12 weeks after treatment,the number of angina pec-toris attacks decreased and the duration of angina pectoris shortened in two groups,the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,CO and LVEF increased and LVEDD decreased in two groups,and the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,the plasma viscosity,whole blood high shear vis-cosity and whole blood low shear viscosity in two groups decreased,and the improvement in study group was greater than that in control group(P＜0.05).12 weeks after treatment,ET-1 decreased and NO increased in two groups,and the improvement in study group was greater than that in control group(P＜0.05).There was no difference in the incidence of adverse reactions between control group(4.76％)and study group(6.35％)(P＞0.05).Conclusion:Yixinshu tablets combined with metoprolol can effectively improve the hemorheology,cardiac function,and endothelial function of patients with coronary heart disease and angina pectoris.
Yixinshu tabletsMetoprololAngina pectoris of coronary heart diseaseCardiac functionHemorheologyVascular en-dothelial function
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