Relationship between RCI,LHR,NLR and Type Ⅱ Respiratory Failure in AECOPD Patients and Its Predictive Value for Poor Short-term Prognosis
Objective:To explore the relationship between red cell index(RCI),lymphocyte/high density lipoprotein ratio(LHR),neutrophil/lymphocyte ratio(NLR)and type Ⅱ respiratory failure in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its predictive value for poor short-term prognosis.Methods:The clinical data of 139 AECOPD patients who visit-ed the Second Affiliated Hospital of Xuzhou Medical University from January 2019 to December 2021 were collected.Patients were di-vided into respiratory failure group(n=47)and non respiratory failure group(n=92)according to whether they had type Ⅱ respiratory fail-ure,the prognosis of above patients within 90 days of discharge were followed up,excluded cases of lost to follow-up and death,patients were divided into poor prognosis group(n=26)and good prognosis group(n=101),the RCI,LHR and NLR ratios were calculated,Multi-variate Logistic regression analysis affecting for poor short-term prognosis of AECOPD patients,the research value of RCI,LHR and NLR ratios in short-term prognosis of AECOPD patients were analyzed by receiver operating characteristic(ROC)curve.Results:NLR and RCI in respiratory failure group were higher than those in non respiratory failure group,LHR was lower than that in non respiratory failure group(P＜0.05).The course of COPD in poor prognosis group was longer than that in good prognosis group,NLR and RCI were higher than those in good prognosis group,body mass index(BMI)and LHR were lower than those in good prognosis group(P＜0.05).Multivariate Logistic regression analysis showed that increased NLR,RCI and decreased LHR were independent risk factors for poor short-term prognosis of AECOPD patients(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of RCI,LHR and NLR in predicting for poor short-term prognosis of AECOPD patients were 0.720,0.681 and 0.770 respectively.The combined AUC of three was 0.863,and the AUC of combined prediction was the largest.Conclusion:RCI,LHR and NLR can evaluate the severity of AE-COPD patients to a certain extent,which are risk factors for poor short-term prognosis,and have a high predictive value for poor short-term prognosis.
Acute exacerbation of chronic obstructive pulmonary diseaseRCILHRNLRPrognosisPredictive value
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