Effects of Wenxin Granule Combined with Dronedarone Hydrochloride Tablets on Oxidative Stress,Myocardial Fibrosis and Peripheral Blood Mononuclear Cell Cx40 and Cx43 in Patients with Paroxysmal Atrial Fibrillation
Objective:To observe the effects of wenxin granule combined with dronedarone hydrochloride tablets on oxidative stress,myocardial fibrosis and peripheral blood mononuclear cell connexin 40(Cx40)messenger RNA(mRNA)and connexin 43(Cx43)mRNA in patients with paroxysmal atrial fibrillation(PAF).Methods:79 PAF patients who were treated in our hospital from March 2020 to December 2022 were selected as study subjects.Patients were divided into control group(39 cases,treated with dronedarone hydrochloride tablets)and study group(40 cases,treated with wenxin granule combined with dronedarone hydrochloride tablets)according to the random number table method.The frequency of atrial fibrillation(AF),resting heart rate,AF duration,oxidative stress index,my-ocardial fibrosis index and the changes of peripheral blood mononuclear cell Cx40mRNA and Cx43mRNA were compared between two groups.Results:Compared with the control group at 12 weeks after treatment,the study group had fewer AF attacks,lower resting heart rate,shorter AF duration,lower malondialdehyde(MDA),procollagen type Ⅲ amino terminal peptide(PⅢNP),matrix metallopro-teinase-2(MMP-2),peripheral blood,monocyte Cx40mRNA,Cx43mRNA,and higher superoxide dismutase(SOD)(P＜0.05).Conclu-sion:Wenxin granule combined with dronedarone hydrochloride tablets in the treatment of PAF patients can effectively improve the clin-ical symptoms of patients,reduce the oxidative stress and myocardial fibrosis injury of patients,and regulate the levels of peripheral blood mononuclear cell Cx40mRNA and Cx43mRNA.
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