Clinical Study of Serum Placental Growth Factor,Angiopoietin-2 Combined with Stress Induced Protein 2 in Predicting Placental Abruption in Patients with Severe Preeclampsia
Objective:To investigate the risk factors of placental abruption in patients with severe preeclampsia(SPE),and explore the predictive value of placental growth factor(PLGF),angiopoietin-2(Ang2)combined with stress induced protein 2(Sestrin2)in severe preeclampsia complicate with placental abruption.Methods:348 SPE patients who were admitted to the Fourth Hospital of Changsha from April 2019 to April 2022 were selected.Patients were grouped according to whether placental abruption occurred,patients were divided into placental abruption group(n=75)and no placental abruption group(n=273).The serum levels of PLGF,Ang2 and Sestrin2 were detected and compared between two groups.The influencing factors in SPE patients with placental abruption were analyzed by uni-variate and multivariate Logistic regression models;The predictive value of PLGF,Ang2 combined with Sestrin2 in SPE patients with placental abruption were analyzed by receiver operating characteristic(ROC)curve.Results:PLGF and Ang2 in placental abruption group were lower than those in no placental abruption group,Sestrin2 was higher than that in no placental abruption group(P＜0.05).SPE com-plicated with placental abruption was related to the history of cesarean section,systolic blood pressure(SBP),diastolic blood pressure(DBP),platelet,urea nitrogen,fibrinogen and serum creatinine(P＜0.05).Multivariate Logistic regression model analysis showed that:high SBP,high DBP,low fibrinogen and high serum creatinine were risk factors for SPE complicated with placental abruption.Sestrin2 level decreased,the increase of PLGF and Ang2 levels was a protective factor for SPE complicated with placental abruption(P＜0.05).The predictive value of serum PLGF,Ang2 combined with Sestrin2 for SPE complicated with placental abruption was better than that of each index alone(P＜0.05).Conclusion:The level of Sestrin2 increas in SPE patients with placental abruption,the levels of PLGF and Ang2 decreas,and combine detection can assist in predicting the occurrence of SPE complicate with placental abruption.High SBP,high DBP,low fibrinogen and high serum creatinine are risk factors for SPE complicate with placental abruption.Sestrin2 level decrease,and the increase of PLGF and Ang2 levels is a protective factor for SPE patients with placental abruption.
Placental growth factorAngiopoietin-2Stress induced protein 2Severe preeclampsiaPlacental abruption
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