Effects of Different Doses of Penehyclidine Hydrochloride before Anesthesia Induction on Oxidative Stress,Serum S100β,NSE and BDNF in Elderly Patients Undergoing Laparoscopic Cholecystectomy
Objective:To investigate the effects of different doses of penehyclidine hydrochloride before anesthesia induction on oxidative stress,serum S100β,neuron-specific enolase(NSE)and brain-derived neurotrophic factor(BDNF)in elderly patients undergo-ing laparoscopic cholecystectomy(LC).Methods:150 elderly patients who underwent elective LC in our hospital from January 2019 to December 2022 were divided into high dose group(penehyclidine hydrochloride 0.015 mg/kg),middle dose group(penehyclidine hy-drochloride 0.01mg/kg)and low dose group(penehyclidine hydrochloride 0.005 mg/kg)according to the random number table method,with 50 cases in each group.The hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)],oxidative stress indexes[super-oxide dismutase(SOD),malondialdehyde(MDA)and total antioxidant capacity(T-AOC)],serum levels of S100β,NSE and BDNF,inci-dence of postoperative cognitive dysfunction(POCD)and incidence of adverse reactions were compared among three groups.Results:HR and MAP in middle dose group were lower than those in low dose group and high dose group from 5 min after laryngeal mask place-ment(T1)to 10 min after stopping pneumoperitoneum(T4)(P＜0.05).The MDA in middle dose group was lower than that in low dose group and high dose group,and the SOD and T-AOC were higher than those in low dose group and high dose group(P＜0.05).S100β and NSE in middle dose group were lower than those in low dose group and high dose group,and BDNF was higher than that in low dose group and high dose group(P＜0.05).There was no significant difference in the incidence of adverse reactions among three groups(P＞0.05).The incidence of POCD in middle dose group was lower than that in low dose group and high dose group(P＜0.05).Conclusion:The application of 0.01 mg/kg penehyclidine hydrochloride before anesthesia induction in elderly LC patients,which can effectively maintain hemodynamic stability and reduce the degree of oxidative stress and brain injury.
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