Effects of Yinchen Wuling Powder and Liraglutide on Glucose and Lipid Metabolism,Insulin Sensitivity and Oxidative Stress in Obese Type 2 Diabetes Patients
Objective:To explore the effects of Yinchen Wuling powder combined with Liraglutide on glucose and lipid metabolism,insulin sensitivity and oxidative stress in obese type 2 diabetes(T2DM)patients.Methods:160 obese T2DM patients with phlegm dampness accumulation type who were admitted to Foshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou Uni-versity of Traditional Chinese Medicine from December 2021 to December 2022 were selected.According to the random number table method,patients were divided into a control group(treated with liraglutide,80 cases)and a study group(treated with Yinchen Wuling powder combined with Liraglutide,80 cases).The efficacy,glucose and lipid metabolism indicators,obesity related indicators,insulin sensitivity,oxidative stress,and incidence of adverse reactions in the two groups were compared.Results:Compared with control group,the total clinical effective rate of study group was higher(P＜0.05).Body mass index(BMI),fasting blood glucose(FBG),waist-to-hip ratio(WHR),2 h postprandial blood glucose(2hPG),malondialdehyde(MDA),glycosylated hemoglobin(HbAlc),homeostasis model insulin resistance index(HOMA-IR),total cholesterol(TC),xanthoxine oxidase(XO),triglyceride(TG),low density lipoprotein choles-terol(LDL-C)of study group after treatment were lower than those of control group(P＜0.05).After treatment,homeostasis model islet βcell function index(HOMA-β),high density lipoprotein cholesterol(HDL-C)and superoxide dismutase(SOD)of study group were higher than those of control group(P＜0.05).There was no difference in the incidence of adverse reactions in two groups(P＞0.05).Conclusion:Yinchen Wuling Powder combined with liraglutide is effective in the treatment of obese T2 DM patients.It can regulate the level of glu-cose and lipid metabolism,reduce insulin sensitivity,reduce oxidative stress,and has certain safety.It is worthy of clinical reference and application.
Yinchen Wuling PowderLiraglutideObese type 2 diabetesGlucose and lipid metabolismInsulin sensitivityOxida-tive stress
NETL
NSTL
万方数据
