摘要
目的:观察通督调神针刺法联合认知功能训练对卒中后认知障碍患者神经递质、肠道菌群的影响 方法:按照随机数字表法将河北省沧州中西医结合医院2021年7月-2022年10月收治的124例卒中后认知障碍患者分为对照组(62例,认知功能训练)和观察组(62例,认知功能训练、通督调神针刺法联合治疗).对比两组简易精神状态检查表(MMSE)、日常生活活动(ADL)、蒙特利尔认知评估量表(MoCA)、血清神经递质[去甲肾上腺素(NE)、神经递质乙酰胆碱(ACh)、5-羟色胺(5-HT)、多巴胺(DA)]、肠道菌群指标.结果:治疗30d后,观察组MMSE、MoCA、ADL评分高于对照组同期(/0.05)治疗30d后,观察组Ach、DA、NE、5-HT高于对照组同期(P＜0.05).治疗30d后,观察组大肠埃希菌、肠球菌低于对照组同期,双歧杆菌、乳杆菌高于对照组同期(P＜0.05).结论:卒中后认知障碍患者在认知功能训练基础上结合通督调神针刺法,认知功能、肠道菌群和神经递质水平显著改善,从而有利于改善患者的日常生活活动能力.
Abstract
Objective:To observe the effect of Tongdu tiaoshen acupuncture combined with cognitive function training on neuro-transmitters and intestinal flora in patients with post stroke cognitive impairment.Methods:According to the random number table method,124 patients with post stroke cognitive impairment who were admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province from July 2021 to October 2022 were divided into control group(62 cases,cognitive function train-ing)and observation group(62 cases,cognitive function training,Tongdu tiaoshen acupuncture combined treatment).Mini-mental state examination(MMSE),activities of daily living(ADL),Montreal cognitive assessment scale(MoCA),serum neurotransmitters[nore-pinephrine(NE),neurotransmitter acetylcholine(ACh),5-hydroxytryptamine(5-HT),dopamine(DA)]and intestinal flora indexes were compared between two groups.Results:30 days after treatment,the scores of MMSE,MoCA and ADL in observation group were higher than those in control group(P＜0.05).30 days after treatment,Ach,DA,NE and 5-HT in observation group were higher than those in con-trol group(P＜0.05).30 days after treatment,Escherichia coli and Enterococcus in observation group were lower than those in control group,and Bifidobacterium and Lactobacillus were higher than those in control group(P＜0.05).Conclusion:Patients with post stroke cognitive impairment combine with Tongdu tiaoshen acupuncture method on the basis of cognitive function training,which can signifi-cantly improve cognitive function,intestinal flora and neurotransmitter levels,which is conducive to improving patients'activities of daily living.
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