Explore the Effect and Mechanism of Taohong Siwu Decoction on Promoting Fracture Healing after PFNA in Elderly Patients with Fntertrochanteric Fracture Based on PI3K/Akt Signaling Pathway
Objective:To explore the efficacy and mechanism of taohong siwu decoction on promoting fracture healing after prox-imal femoral nail antirotation(PFNA)in elderly patients with fntertrochanteric fracture based on phosphatidylinositol 3-kinase(PI3K)/serine protein kinase(Akt)signaling pathway.Methods:90 elderly patients with fntertrochanteric fracture treated with PFNA who were admitted to Suining Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were selected,patients were divided into control group and study group according to the random number table method,45 cases each.Control group received routine intervention after operation,and study group received taohong siwu decoction on the basis of control group.The traditional Chinese medicine syn-drome scores,fracture healing time,Harris hip function scores,hemorheology,PI3K/Akt signaling pathway related indicators were com-pared between two groups.Results:The hip pain,pain,fatigue,limb weakness,dizziness,insomnia,forgetfulness,spontaneous sweating,fear of wind and cold,chest tightness,shortness of breath,skin nails,pale complexion score and total score in study group were lower than those in control group after treatment(P＜0.05).The fracture healing time in study group was shorter than that in control group,Harris hip function score was higher than that of control group(P＜0.05).The hematocrit,plasma specific viscosity,whole blood specific viscosity and erythrocyte electrophoresis time in study group were lower than those in control group(P＜0.05).PI3K mRNA and Akt mRNA in study group were higher than those in control group after treatment(P＜0.05).Conclusion:Elderly patients with fntertrochanteric fracture are treat with taohong siwu decoction after PFNA surgery,which can promote the clinical prognosis of patients,reduce traditional Chinese medicine syndrome scores,promote the recovery of hip joint function,shorten the healing time of fractures,improve hemorheology of the body,and regulate the expression of PI3K/Akt signaling pathway.
PI3K/Akt signaling pathwayTaohong siwu decoctionElderlyFntertrochanteric fractureProximal femoral nail antiro-tationFracture healing
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