Effect of Different Doses of Dexmedetomidine on Hemodynamics and Pain Level in Patients with Cerebral Infarction Undergoing Interventional Therapy
Objective:The effects of different doses of dexmedetomidine on hemodynamics and pain level in patients with cerebral infarction were analyzed.Methods:A total of 90 patients with cerebral infarction who underwent interventional surgery in our hospital from June 2019 to December 2022 were selected for the study,and 30 patients with intraoperative adjuvant use of normal saline were included in the control group,and 30 patients with adjuvant use of 0.2 μg·kg-1 dexmedetomidine were included in the low-dose group.Thirty patients receiving 0.6 μg·kg1 dexmedetomidine were included in the high-dose group.Respiratory recovery time,orientation recovery time,extubation time and incidence of adverse reactions were recorded in the three groups.The hemodynamics[mean arterial pressure(MAP),diastolic pressure(DBP),systolic blood pressure(SBP),heart rate(HR)]and pain factors[serum Substance P(SP),5-hydroxytryptamine(5-HT)]of the three groups were measured at the time of entry(T0),30 minutes after surgery(T1),after surgery(T3),and 12 hours after surgery(T4).Results:There was no significant difference in respiratory recovery time,orientation recovery time and extubation time among the three groups(P＞0.05).Compared with the control group,the levels of MAP,HR,SBP and DBP in the low-dose and high-dose groups at T1 and T2 were lower.Compared with the low-dose group,the levels of MAP,HR,SBP and DBP in the high-dose group at T1 and T2 were lower(P＜0.05).Compared with the control group,the levels of SP and 5-HT in T1,T2 and T3 periods were lower in low-dose and high-dose groups.Compared with low-dose group,the levels of SP and 5-HT in T1,T2 and T3 periods in high-dose group were lower(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion:Both high-dose and low-dose dexmedetomidine can help stabilize hemodynamics and relieve pain in patients with cerebral infarction undergoing interventional therapy,and the effect of high-dose dexmedetomidine is more obvious.
Different dosesDexmedetomidineInterventional therapyAnesthetic effectHemodynamicsPain
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万方数据
维普
