Relationship between Serum CTRP4,CTRP5,CTRP6 and Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Heart Disease
Objective:To investigate the relationship between serum complement 1q/tumor necrosis factor related protein(CTRP)4,CTRP5,CTRP6 and coronary artery disease in patients with type 2 diabetes mellitus(T2DM)and coronary heart disease(CHD).Methods:100 patients with T2DM combined with CHD who were admitted to our hospital from March 2021 to July 2021 were selected as the merged group.According to the SYNTAX score,they were divided into moderate to severe lesion group of 44 and mild lesion group of 56.100 patients with pure T2DM who were admitted during the same period were selected as the T2DM group,and 80 healthy volunteers who underwent physical examination during the same period were selected as control group.Serum levels of CTRP4,CTRP5,and CTRP6 were detected using enzyme-linked immunosorbent assay.Spearman correlation analysis was used to investigate the correlation between SYNTAX score and serum levels of CTRP4,CTRP5,and CTRP6 in patients with T2DM and CHD.Multivariate logistic regression analysis was used to investigate the influencing factors of moderate to severe coronary artery disease in patients with T2DM and CHD.Results:Serum CTRP4 and CTRP5 levels were increased and CTRP6 levels were decreased in the control,T2DM and combined groups in that order(P＜0.05).Spearman correlation analysis showed that SYNTAX scores in patients with T2DM combined with CHD were positively correlated with serum CTRP4 and CTRP5 levels(rs=0.820,0.833,all P＜0.001)and negatively correlated with CTRP6 levels(rs=-0.838,P＜0.001).Multi-factor logistic regression analysis showed that prolonged duration of T2DM and elevated glycosylated hemoglobin(HbA1c),CTRP4,and CTRP5 were independent risk factors for moderate to severe coronary artery disease in patients with T2DM combined with CHD,and elevated CTRP6 was an independent protective factor(P＜0.05).Conclusion:Increased serum CTRP4 and CTRP5 levels and decreased CTRP6 levels were independently associated with exacerbation of coronary artery lesions in patients with T2DM combined with CHD,and may be indicators for the assessment of coronary artery lesions in patients with T2DM combined with CHD.
Type 2 diabetesCoronary heart diseaseCTRP4CTRP5CTRP6Coronary artery disease
NETL
NSTL
万方数据
维普
