To Analyze the Clinical Characteristics and Prognostic Factors of Coagulation Disorders in Patients with Sepsis
Objective:To explore the sepsis patients of blood coagulation dysfunction clinical characteristics and prognosis influencing factors.Methods:A total of 80 patients with sepsis admitted to our hospital from September 2019 to January 2023 were selected as the subjects of this study.Coagulation function tests were carried out on all patients.According to the test results,patients were divided into abnormal coagulation function group(n=60)and normal coagulation function group(n=20).Analysis of abnormal blood coagulation dysfunction and clinical features in patients with normal and abnormal blood coagulation dysfunction and disease severity in patients with normal,and on the basis of the prognosis of patients with sepsis,it can be divided into survival group(n=64)and death group(n=16)the prognosis of patients with sepsis of single factor and multi-factor Logistic regression analysis.Results:There were no significant differences in the mean arterial pressure,body temperature,white blood cell count(WBC),fibrinogen(FIB)and thrombin time(TT)indexes between normal and abnormal groups(P＞0.05).The levels of respiration,pulse rate,procalcitonin(PCT),C-reactive protein(CRP),partial thromboplastin time(APTT),prothrombin time(PT)and PLT index were relatively high in patients with abnormal coagulation function group(P＜0.05).Compared with sepsis patients with normal coagulation function,patients with abnormal coagulation function had higher incidence of acute kidney injury(AKI)and acute respiratory distress syndrome(ARDS),acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)and acute physiological function assessment(SOFA)scores,and longer ICU stay(P＜0.05).Mechanical ventilation and hospital stay were compared(P＞0.05);In the analysis of prognostic factors in patients with sepsis,the results showed that age,body mass index(BMI),gender,history of diabetes and history of hypertension did not have a great impact on the prognosis of patients with sepsis(P＞0.05),while PT,PCT,APTT,CRP,SOFA score and APACHE Ⅱ score had a serious impact on the prognosis of patients with sepsis.All indexes in death group were higher than those in survival group(P＜0.05).The single factors affecting the prognosis of patients with sepsis were assigned values and included in the Logistic regression analysis.With PCT,PT,APTT,CRP,SOFA and APACHE Ⅱ scores as independent variables,the results showed that PCT,PT,CRP,SOFA,APACHE Ⅱscore is the independent risk factors affecting the prognosis of patients with sepsis(P＜0.05).Conclusion:The occurrence of coagulation disorders in patients with sepsis will affect the clinical related indicators,thus increasing the severity of the disease.According to the prognosis of patients with sepsis,the study results show that PT,PCT,CRP,SOFA and APACHE Ⅱ scores will have adverse effects on the prognosis of patients with sepsis.Can provide certain reference for clinical evaluation of prognosis of sepsis.
NETL
NSTL
万方数据
维普
