Serum STAT3,HIF-3α the Predictive Value of the Expression of mRNA in the Severity of Retinopathy in Premature Infants
Objective:To analyze serum signal transduction and transcription activating factor 3(STAT3)and hypoxia inducible factor 3α(HIF-3α)The predictive value of the expression of β-lactamase for the severity of retinopathy in premature infants.Methods:A retrospective analysis was conducted on 80 premature infants with ROP who were diagnosed and treated in our hospital from April 2021 to April 2022.According to the severity classification of ROP in the International Classification of ROP,they were divided into mild ROP group(n=40)and severe ROP group(n=40),and healthy premature infants in the same period were selected as the control group(n=40).Compare serum STAT3 and HIF-3α between different groups Level difference,using Pearson test to analyze serum STAT3 and HIF-3α Correlation between levels and severity of ROP,Multivariate logistic regression analysis was used to screen the risk factors for predicting ROP,and the value of each risk factor in predicting the severity of ROP was analyzed using the subject work characteristic curve(ROC).Results:Serum STAT3,HIF-3α in the mild and severe ROP groups the levels were higher in the severe ROP group than in the mild ROP group(P＜0.05).Pearson correlation test showed that serum STAT3,HIF-3α The level is positively correlated with the severity of ROP(r=0.812,0.796,P＜0.05).Multivariate logistic regression analysis showed that serum STAT3,HIF-3α Level is an independent risk factor for severity of ROP(OR=3.706,3.219,P＜0.05).ROC curve analysis results show that serum STAT3,HIF-3α Level changes are of great value in predicting the severity of ROP.Conclusion:As the condition worsens,serum STAT3 and HIF-3α in children with ROP The two indicators have high value in predicting the condition of patients with ROP and can be used to assess the severity of the disease.
Signal transduction and transcription activating factor 3Transcription activating factor 3Retinopathy of premature infants
NETL
NSTL
万方数据
维普
