Study of the Relationship between Serum Antithrombin Ⅲ and Plasma Monoamine Oxidase and Acute Coronary Syndrome and Their Efficacy in Predicting Major Cardiovascular Adverse Events in the Near Future after Interventional Procedures
Objective:To investigate the relationship between serum antithrombin Ⅲ(ATⅢ)and plasma monoamine oxidase(MAO)and acute coronary syndrome and their predictive efficacy for major adverse cardiovascular events in the near future after interventional procedures.Methods:Eighty-five patients with acute coronary syndrome admitted to our hospital from January 2020 to January 2023 were selected as study subjects,and the patients were grouped according to their cardiology non-ST-segment elevation acute coronary syndrome ischemia assessment(GRACE)scores,and 20 patients with GRACE scores＞140 were divided into the high-risk group,30 patients with scores 109-140 were divided into the medium In addition,40 healthy patients who came to our hospital for physical examination at the same period were selected as the control group,and serum ATⅢ and plasma MAO expression levels of the four groups were compared,and the correlation between serum ATⅢ and plasma MAO and the severity of acute coronary syndrome was analyzed.Subsequently,85 cases with or without recent adverse cardiovascular events(MACE)after PCI for acute coronary syndrome were divided into non-MACE group(n=64)and MACE group(n=21),and the clinical characteristics,serum ATⅢ and plasma MAO expression levels of the two groups were compared,and the correlation between serum ATⅢ and plasma MAO on recent major adverse predictive efficacy of cardiovascular events after acute coronary syndrome intervention.Results:There were differences in the levels of AT Ⅲ and MAO among the four groups.The level of AT Ⅲ in the high-risk group was significantly lower than that in the medium-risk group,the low-risk group and the control group,and the level of MAO in the high-risk group was higher than that in the medium-risk group,the low-risk group and the control group(P＜0.05);Spearman correlation analysis showed that AT Ⅲ and MAO were positively correlated with the severity of acute coronary syndrome,while MAO was negatively correlated with the severity of acute coronary syndrome(P＜0.05);There was no difference between the non-MACE group and the MACE group in terms of age,cardiac function grading,left ventricular ejection fraction,TIMI score,AT Ⅲ and MAO expression level(P＜0.05);The results of logistic regression analysis showed that ATⅢ and MAO were independent risk factors for major adverse cardiovascular events in the near future after interventional procedures for acute coronary syndromes(P＜0.05).Conclusion:Serum ATⅢ and plasma MAO levels were significantly correlated with the severity of acute coronary syndrome,and ATⅢ and MAO were independent risk factors for recent major adverse cardiovascular events after interventional procedures for acute coronary syndrome.It is suggested that clinically,for patients with acute coronary syndrome with reduced ATⅢ and elevated MAO,timely measures should be taken to prevent the occurrence of recent adverse cardiovascular events.
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NSTL
万方数据
维普
