Value of Contrast-Enhanced Ultrasound Combined with Serum ALT and AST Ratio in the Differential Diagnosis of Gastrointestinal Stromal Tumor and Colorectal Cancer with Liver Metastasis
Objective:To explore the value of contrast-enhanced ultrasound(CEUS)combined with serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)ratio(LSR)in the differential diagnosis of gastrointestinal stromal tumor liver metastasis(GISTLM)and colorectal cancer liver metastasis(CRCLM).Methods:The clinical data of 34 patients with GISTLM(GISTLM group)and 48 patients with CRCLM(CRCLM group)admitted to Yibin Second People's Hospital from January 2019 to December 2022 were selected.All patients underwent CEUS examination and serum ALT and AST tests before operation.All patients were confirmed by pathology after operation.The differences of CEUS quantitative parameters and serum LSR between the two groups were compared;The differential diagnostic efficacy of CEUS quantitative parameters and serum LSR alone or in combination for GISTLM was analyzed by drawing the subject working characteristic curve(ROC)and calculating the area under the curve(AUC).Results:The proportion of cystic/cystic-solid components and anechoic/hypoechoic of liver lesions in GISTLM group was significantly higher than that in CRCLM group(P＜0.05).CEUS quantitative parameters[rise time(RT),peak intensity(PI),peak time(TTP),mean transit time(MTT)]and LSR in GISTLM group were significantly higher than those in CRCLM group(P＜0.05).Compared with single diagnosis,the AUC,Yoden index,sensitivity and specificity of CEUS quantitative parameters combined with serum LSR in diagnosis of GISTLM were the highest(P＜0.05).Conclusion:CEUS quantitative parameters combined with serum LSR can help improve the differential diagnosis of GISTLM and CRCLM,and provide real and objective clinical evidence for the selection of clinical treatment plan.
Contrast-enhanced ultrasoundALT to AST ratioLiver metastasis of gastrointestinal stromal tumorLiver metastasis of colorectal cancerDifferential diagnosiss
NETL
NSTL
万方数据
维普
