Relationship between Serum FKN,APC and the Pathogenetic Condition and Poor Prognosis in Elderly Patients with Community-Acquired Pneumonia
Objective:To investigate the relationship between serum fractalkine(FKN),activated protein C(APC)and the pathogenetic condition and poor prognosis in elderly patients with community-acquired pneumonia(CAP).Methods:314 elderly CAP patients who were admitted to Weifang People's Hospital from January 2020 to January 2023 were selected as CAP group,patients were divided into low risk group(104 cases),medium risk group(123 cases)and high risk group(87 cases)according to the severity of the disease,patients were divided into death group(65 cases)and survival group(249 cases)according to the 30 days survival status after admission,another 100 healthy elderly people who underwent physical examination during the same period were selected as control group.Serum FKN and APC levels were detected by enzyme-linked immunosorbent assay.The predictive value of serum FKN and APC levels of poor prognosis in elderly CAP patients were analyzed by receiver operating characteristic(ROC)curve.The influencing factors of poor prognosis in elderly CAP patients were analyzed by multivariate logistic regression.Results:Compared with control group,serum FKN level increased in CAP group,and APC level decreased(P＜0.05).Serum FKN levels of elderly CAP patients in low risk group,medium risk group and high risk group increased in turn,and APC levels decreased in turn(P＜0.05).Multivariate Logistic regression analysis showed that,high risk of illness,mechanical ventilation and increased C-reactive protein(CRP)and FKN were independent risk factors of poor prognosis in elderly CAP patients,and the increase of APC was an independent protective factor(P＜0.05).ROC curve analysis showed that,the area under the curve of FKN,APC levels alone and combined to predict poor prognosis in elderly CAP patients was 0.783,0.789 and 0.870 respectively,the predictive value of the combination of the two for the poor prognosis of elderly CAP patients is greater than that of each index alone.Conclusion:Elevated serum FKN levels and decreased APC levels are involved in the progression of elderly CAP patients,and Serum FKN combine with APC can better predict the poor prognosis of elderly CAP patients.
ElderlyCommunity-acquired pneumoniaFractalkineActivated protein CPathogenetic conditionPrognosis
NETL
NSTL
万方数据
维普
