Study on the Relationship between CD64 Index,sCD14,sCD163 and Severe Pulmonary Infection after Thoracoscopic Radical Resection of Lung Cancer
Objective:To investigate the relationship between CD64 index,soluble leukocyte differentiation antigen 14(sCD14),soluble leukocyte differentiation antigen 163(sCD163)and severe pulmonary infection after thoracoscopic radical resection of lung cancer.Methods:415 patients with non-small cell lung cancer(NSCLC)who underwent thoracoscopic radical resection of lung cancer in Nantong Tumor Hospital from January 2020 to January 2023 were selected.Patients were divided into infection group(21 cases)and non-infection group(394 cases)according to whether severe pulmonary infection occurred after operation.Peripheral blood CD64 index and serum levels of sCD14 and sCD163 were detected.Multivariate Logistic regression analysis of the factors affecting the incidence of severe lung infection after thoracoscopic radical lung cancer surgery.The value of receiver operating characteristic(ROC)curve analysis of CD64 index,sCD14 and sCD163 in predicting severe lung infection after thoracoscopic radical lung cancer surgery.Results:The peripheral blood CD64 index,serum sCD14 and sCD163 levels in infection group were higher than those in non-infection group(P＜O.05).Multivariate Logistic regression analysis showed that high CD64 index,sCD14,sCD163 and procalcitonin(PCT)were risk factors for severe pulmonary infection after thoracoscopic radical resection of lung cancer(P＜0.05),and high peak expiratory flow(PEF)was a protective factor(P＜0.05).The area under the curve of CD64 index,sCD14,sCD163 and PCT in predicting severe pulmonary infection after thoracoscopic radical resection of lung cancer was 0.834,0.815,0.842 and 0.784 respectively,the area under the curve of combined prediction was 0.928,which was higher than that of single prediction.Conclusion:The increase levels of serum CD64 index,sCD14,sCD163 and PCT are risk factors for severe pulmonary infection after thoracoscopic radical resection of lung cancer.The combination of CD64 index,sCD14,sCD163 and PCT can predict the risk of severe pulmonary infection after operation.
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