Study on the Clinical Value of PLR,NLR,SIRI and HSP90αin Predicting EGFR Gene Mutation in Patients with Non-Small Cell Lung Cancer in Qinghai Area
Objective:To investigate the clinical value of platelet/lymphocyte ratio(PLR),neutrophil/lymphocyte ratio(NLR),systemic inflammatory response index(SIRI)and heat shock protein 90α(HSP90α)in predicting epidermal growth factor receptor(EGFR)gene mutation in patients with non-small cell lung cancer(NSCLC)in Qinghai area.Methods:135 NSCLC patients who underwent EGFR gene tested in Qinghai area admitted to Affiliated Hospital of Qinghai University from March 2020 to March 2023 were selected as research objects,patients were divided into EGFR mutant group(64 cases)and wild type group(71 cases)according to the occurrence of EGFR mutation.PLR,NLR,SIRI and HSP90α were detected.The influencing factors of EGFR gene mutation wew analyzed by multivariate Logistic regression,the efficacy of PLR,NLR,SIRI and HSP90α in predicting EGFR gene mutation in NSCLC patients were analyzed by receiver operating characteristic(ROC)curve.Results:The plasma HSP90α level in EGFR mutant group was higher than that in wild type group(P＜0.05),and PLR,NLR and SIRI were lower than those in wild type group(P＜0.05).Multivariate Logistic regression analysis showed that,female,adenocarcinoma and high HSP90α were risk factors for EGFR gene mutation in NSCLC patients(P＜0.05),while high PLR,NLR and SIRI were protective factors(P＜0.05).The area under the curve of PLR,NLR,SIRI and HSP90α in predicting EGFR gene mutation in NSCLC patients was 0.783,0.826,0.815 and 0.811 respectively,the area under the curve of combined prediction was 0.932,which was higher than that of single prediction.Conclusion:The PLR,NLR and SIRI of NSCLC patients with EGFR gene mutation in Qinghai area are decrease,and HSP90α is increase.The combination of PLR,NLR,SIRI and HSP90α has a high predictive value for the occurrence of EGFR gene mutation.
Non-small cell lung cancerPLRNLRSIRIHSP90αEGFR Gene mutationPredictive value
NETL
NSTL
万方数据
维普
