丙戊酸钠联合奥卡西平治疗小儿癫痫的疗效及对患儿脑电图、认知功能和血清神经因子的影响
The Efficacy of Sodium Valproate Combined with Oxcarbazepine in the Treatment of Pediatric Epilepsy and Its Effects on Electroencephalogram,Cognitive Function,and Serum Neurotrophic Factors
刘幸 1王敏 2张蕾 3王婉娟 1刘晓庆1
作者信息
- 1. 西北妇女儿童医院药剂科 陕西西安 710061
- 2. 西安交通大学附属儿童医院儿科 陕西西安 710003
- 3. 陕西省中医医院药剂科 陕西西安 710003
- 折叠
摘要
目的:评价丙戊酸钠联合奥卡西平治疗小儿癫痫的疗效及对患儿脑电图、认知功能和血清神经因子的影响.方法:选入2019年1月～2022年12月收治的癫痫患儿104例,根据治疗方法不同分为单药组(丙戊酸钠治疗)和联合组(丙戊酸钠+奥卡西平治疗),各52例.评价两组的临床疗效、脑电图、认知功能、血清神经因子等指标,并进行统计比较.结果:联合组治疗后癫痫发作频率及每次持续时间显著低于单药组(P＜0.05),EEG显示痫样放电率、总异常亦明显低于单药组(P＜0.05);联合组治疗总有效率94.23％,明显高于单药组的71.15％(P＜0.05);两组治疗后WISC-CR量表VIQ、PIQ和FIQ评分均较治疗前明显升高(P＜0.05),而联合组升高幅度更大,与单药组差异显著(P＜0.05);治疗前,两组血清BDNF、NSE和S-100β蛋白无明显差异(P＞0.05),而治疗后,联合组血清BDNF水平明显高于单药组、NSE和S-100β水平显著低于单药组(P＜0.05);两组不良反应总发生率无差异(P＞0.05).结论:丙戊酸钠联合奥卡西平治疗小儿癫痫疗效较好,可有效缓解临床症状,控制脑部异常放电,改善认知功能,调节血清神经因子水平,且安全性良好.
Abstract
Objective:To evaluate the efficacy of sodium valproate combined with oxcarbazepine in the treatment of pediatric epilepsy and its effects on electroencephalogram,cognitive function and serum neurotrophic factors.Methods:104 children with epilepsy from January 2019 to December 2022 were selected and divided into a monotherapy group(sodium valproate treatment)and a combination group(sodium valproate+oxcarbazepine treatment)based on different treatment methods,with 52 cases in each group.Evaluate and compare the clinical efficacy,EEG,cognitive function,serum neurofactors,and other indicators between the two groups.Results:After treatment,the frequency and duration of seizures in the combination group were lower than those in the monotherapy group(P＜0.05),and the EEG showed a lower epileptiform discharge rate and total abnormality compared to the monotherapy group(P＜0.05).The total effective rate of the combination group was 94.23％,higher than 71.15％in the monotherapy group(P＜0.05).After treatment,the scores of VIQ,PIQ,and FIQ on the WISC-CR scale in both groups were higher than before treatment(P＜0.05),while the increase in the combination group was greater than that in the monotherapy group(P＜0.05).There was no difference in serum BDNF,NSE and S-100β between the two groups before treatment(P＞0.05),but after treatment,the serum BDNF level in the combination group were higher than that in the monotherapy group,NSE and S-100β levels were lower than those in the monotherapy group(P＜0.05).There was no difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Valproate combined with oxcarbamazepine is effective in pediatric epilepsy,which can effectively relieve clinical symptoms,control abnormal brain discharge,improve cognitive function,regulate the level of serum nerve factors,and have good safety.
关键词
小儿癫痫/丙戊酸钠/奥卡西平/疗效/脑电图/认知功能/血清神经因子Key words
Pediatric epilepsy/Sodium valproate/Oxcarbazepine/Efficacy/EEG/Cognitive function/Serum Neurofactors引用本文复制引用
基金项目
陕西省科技厅一般项目-青年项目(2022JQ-853)
出版年
2024
NETL
NSTL
维普
万方数据