The Efficacy of Sodium Valproate Combined with Oxcarbazepine in the Treatment of Pediatric Epilepsy and Its Effects on Electroencephalogram,Cognitive Function,and Serum Neurotrophic Factors
Objective:To evaluate the efficacy of sodium valproate combined with oxcarbazepine in the treatment of pediatric epilepsy and its effects on electroencephalogram,cognitive function and serum neurotrophic factors.Methods:104 children with epilepsy from January 2019 to December 2022 were selected and divided into a monotherapy group(sodium valproate treatment)and a combination group(sodium valproate+oxcarbazepine treatment)based on different treatment methods,with 52 cases in each group.Evaluate and compare the clinical efficacy,EEG,cognitive function,serum neurofactors,and other indicators between the two groups.Results:After treatment,the frequency and duration of seizures in the combination group were lower than those in the monotherapy group(P＜0.05),and the EEG showed a lower epileptiform discharge rate and total abnormality compared to the monotherapy group(P＜0.05).The total effective rate of the combination group was 94.23％,higher than 71.15％in the monotherapy group(P＜0.05).After treatment,the scores of VIQ,PIQ,and FIQ on the WISC-CR scale in both groups were higher than before treatment(P＜0.05),while the increase in the combination group was greater than that in the monotherapy group(P＜0.05).There was no difference in serum BDNF,NSE and S-100β between the two groups before treatment(P＞0.05),but after treatment,the serum BDNF level in the combination group were higher than that in the monotherapy group,NSE and S-100β levels were lower than those in the monotherapy group(P＜0.05).There was no difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Valproate combined with oxcarbamazepine is effective in pediatric epilepsy,which can effectively relieve clinical symptoms,control abnormal brain discharge,improve cognitive function,regulate the level of serum nerve factors,and have good safety.
NETL
NSTL
万方数据
维普
