The Role of Serum LPA,AngⅡ and β2-MG in Disease Monitoring in Elderly Patients with Type 2 Diabetes and Their Correlation with Insulin Resistance
Objective:To analyze the role of serum lysophosphatidylic acid(LPA),angiotensin Ⅱ(AngⅡ)and β2-microglobulin(β2-MG)in disease monitoring in elderly patients with type 2 diabetes mellitus and their correlation with insulin resistance.Methods:106 elderly patients with type 2 diabetes admitted to our hospital from January 2020 to June 2023 were selected as the observation group,of which 34 patients were complicated with kidney disease(diabetic nephropathy group)and 72 patients were not complicated with kidney disease(simple diabetes group).Another 106 healthy subjects were selected as control group.The expression levels of serum LPA,AngⅡand β2-MG in all participants were detected,and the relationship between serum LPA,AngⅡ and β2-MG and nephropathy in elderly patients with type 2 diabetes was analyzed by multivariate Logistic regression.Pearson correlation was used to analyze the relationship between serum LPA,AngⅡ and β2-MG expression levels and fasting blood glucose(FPG),2 h postmeal blood glucose(2hPG),fasting insulin(FINS),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR)and islet beta cell function index(HOMA-β).Results:The levels of serum LPA,AngⅡ and β2-MG in observation group were higher than those in control group(P＜0.05).The expression levels of serum LPA,AngⅡ and β2-MG in diabetic nephropathy group were significantly higher than those in simple diabetic group(P＜0.05).Multivariate Logistic regression analysis showed that serum LPA,AngⅡ and β2-MG were independent predictors of nephropathy in elderly patients with type 2 diabetes(P＜0.05).The expression levels of FPG,2hPG,FINS and HbA1c in observation group were higher than those in control group,HOMA-IR was higher than that in control group,HOMA-β was lower than that in control group(P＜0.05).By Pearson correlation analysis,serum LPA,AngⅡ and β2-MG in elderly patients with type 2 diabetes were positively correlated with FPG,2hPG,FINS,HbA1c and HOMA-IR(P＜0.05),and negatively correlated with HOMA-β(P＜0.05).Conclusion:The elevated levels of serum LPA,AngⅡ and β2-MG have a certain effect on the disease monitoring of elderly patients with type 2 diabetes,and are closely related to the degree of insulin resistance,which is worthy of further study and application.
Old ageType 2 diabetesLysophosphatidic acidAngiotensin Ⅱβ2-microglobulinDisease monitoringInsulin resistance
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