Based on TLR4/MyD88/NF-κB Signaling Pathway to Explore Efficacy and Mechanism of Anchang Decoction Combined with Moxibustion in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Syndrome
Based on TLR4/MyD88/NF-κB Signaling Pathway to Explore Efficacy and Mechanism of Anchang Decoction Combined with Moxibustion in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Syndrome
Objective:Based on Toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)signaling pathway to explore efficacy and mechanism of anchang decoction combined with moxibustion in the treatment of diarrhea-pre-dominant irritable bowel syndrome(IBS)with liver stagnation and spleen deficiency syndrome.Methods:According to random number table method,108 patients with diarrhea type IBS who were admitted to the First Affiliated Hospital of Guangzhou University of Tradi-tional Chinese Medicine from April 2019 to December 2022 were divided into control group(treated with conventional drugs combined with moxibustion,n=54)and study group(treated with Anchang Tang on the basis of the control group,n=54).The efficacy,chinese medicine syndrome total scores,IBS symptom severity questionnaire(IBS-SSS)score,intestinal barrier function index,TLR4/MyD88/NF-κB signaling pathway related messenger ribonucleic acid(mRNA)expression level were compared between two groups.Results:The total clinical effective rate in study group was higher than that in control group(P＜0.05).Chinese medicine syn-drome total scores and IBS-SSS scores in two groups decreased after treatment,and study group was lower than that of control group(P＜0.05).The intestinal fatty acid binding protein(IFABP),D-lactate and diamine oxidase(DAO)decreased in two groups after treat-ment,and study group was lower than that of control group(P＜0.05).TLR4,MyD88 and NF-κB mRNA decreased expression in two groups after treatment,and study group was lower than that of control group(P＜0.05).Conclusion:Anchang decoction combine with moxibustion can effectively improve the clinical symptoms and intestinal barrier function of diarrhea-predominant IBS patients with liver depression and spleen deficiency syndrome,and the curative effect is good,which may be relate to the regulation of TLR4/MyD88/NF-κB signaling pathway.
维普
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