Study on the Relationship between Serum C-reactive Protein,Albumin,S100B Protein and the Severity of Craniocerebral Injury and Its Complication with Acute Traumatic Coagulation Disease
Objective:To explore the relationship between serum C-reactive protein(CRP),albumin,S100B protein and the sever-ity of traumatic brain injury and its complication with acute traumatic coagulation disease.Methods:80 patients with brain injury admit-ted to our hospital from March 2020 to March 2023 were selected as the research subjects.All patients were evaluated using the Glass Coma Score(GCS),and the severity of the brain injury was determined based on the score results.25 patients with a GCS score of ≤ 8 were divided into a severe group,and 55 patients with a GCS score of＞8 were divided into a non severe group.Compare the expression levels of serum CRP,albumin,and S100B protein between two groups of patients.Subsequently,80 patients with traumatic brain injury were divided into an acute traumatic coagulation disease group(n=20)and a non acute traumatic coagulation disease group(n=60)based on whether they were complicated with acute traumatic coagulation disease.The general clinical situation of the two groups of patients was compared,and the predictive value of serum CRP,albumin,and S100B protein for the occurrence of acute traumatic coagulation dis-ease in patients with traumatic brain injury was analyzed.Results:There was no difference in albumin levels among patients with differ-ent severity of brain injury(P＞0.05),but there was a difference in CRP and S100B protein levels.The CRP level in the severe group was higher than that in the non severe group,while the S100B protein level was lower than that in the non severe group(P＜0.05);The Spear-man correlation analysis results showed that there was no significant correlation between albumin and the severity of brain injury(P＞0.05),CRP was positively correlated with the severity of brain injury,and S100B protein was negatively correlated with the severity of brain injury(P＜0.05);There was no significant difference in gender,age,BMI,and type of brain injury between the acute traumatic coagula-tion disease group and the non acute traumatic coagulation disease group(P＞0.05).However,there was a significant difference in the range of brain contusion,treatment time,GCS score,shock index,CRP,albumin,and S100B protein levels between the acute traumatic coagulation disease group and the non acute traumatic coagulation disease group(P＜0.05);The results of logistic regression analysis showed that GCS score,shock index,CRP,and albumin were independent influencing factors for acute traumatic coagulation disease after brain injury(P＜0.05).Conclusion:The detection of CRP and S100B protein on admission can assist the severity of craniocerebral injury early,and when patients with high CRP level and low S100B protein and albumin level,they should be alert to the occurrence of acute traumatic coagulopathy,and take timely measures to intervene for patients.
万方数据
维普
