Effects of Propofol Target Controlled Infusion Combined with Dexmedetomidine on Serum Inflammatory Factors and Brain Injury Indexes in Patients with Craniocerebral Trauma Intracranial Hematoma Removal
Objective:To observe the effects of propofol target controlled infusion combined with dexmedetomidine on serum in-flammatory factors and brain injury indexes in patients with craniocerebral trauma intracranial hematoma removal.Methods:A total of 115 patients with intracranial hematoma removal for craniocerebral trauma admitted to the Department of Anesthesiology of the 901st Hospital of the Joint Logistics Support Force during 2016～2021 were selected.Patients were divided into control group and experimental group by random number table method,with 57 cases and 58 cases respectively.Patients in control group received propofol target con-trolled infusion,and patients in experimental group received propofol target controlled infusion combined with dexmedetomidine.The recovery quality(recovery time,listen to the instruction eye opening time,retention time in recovery room),hemodynamic indexes[heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP)],inflammatory factors[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],brain injury indexes[neuron-specific enolase(NSE),S100β,brain-derived neurotrophic factor(BDNF)]were compared between two groups,and the perioperative adverse reactions in two groups were observed.Results:The recov-ery time,listen to the instruction eye opening time and retention time in recovery room in experimental group were shorter than those in control group(P＜0.05).HR,SBP and DBP in experimental group were lower than those in control group at the time point of tracheal in-tubation(T1)to extubation(T4)(P＜0.05).The levels of IL-1β,TNF-α and IL-6 in experimental group were lower than those in control group at 48h after operation(P＜0.05).The NSE and S100β in experimental group were lower than those in control group at 48 h after op-eration,and BDNF was higher than that in control group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Propofol target controlled infusion combine with dexmedetomidine for patients with craniocerebral trauma intracranial hematoma removal,which can maintain hemodynamic stability,reduce inflammatory response and brain injury,pro-mote recovery after operation,and the incidence of adverse reactions are not increase significantly.
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