Study on the Relationship between Serum Lp-PLA2,FGF-23 and Poor Maturation of Autologous Arteriovenous Fistula in Uremic Hemodialysis Patients
Objective:To investigate the relationship between serum lipoprotein-associated phospholipase A2(Lp-PLA2),fibrob-last growth factor-23(FGF-23)and poor maturation of autologous arteriovenous fistula(AVF)in uremic hemodialysis patients.Methods:170 uremia patients who were received hemodialysis in the Nephrology Department of 908 Hospital of Joint Logistics Support Force from February 2021 to December 2022 were selected,patients were divided into 57 cases of poor maturity group and 113 cases of maturity group according to the maturity of AVF.Serum Lp-PLA2 and FGF-23 levels were detected by enzyme-linked immunosorbent assay.The influencing factors of poor AVF maturation in uremic hemodialysis patients were analyzed by multivariate Logistic regression.The pre-dictive efficacy of serum Lp-PLA2 and FGF-23 levels on poor AVF maturation in uremic hemodialysis patients were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum Lp-PLA2 and FGF-23 in poor maturity group were higher than those in maturity group(P＜0.05).Multivariate Logistic regression analysis showed that,increased serum phosphorus,low-density lipoprotein cholesterol(LDL-C),Lp-PLA2 and FGF-23 were independent risk factors for poor AVF maturation in uremic hemodialysis patients(P＜0.05).ROC curve analysis showed that,the area under the curve(AUC)of serum Lp-PLA2 and FGF-23 levels alone and in combina-tion to predict poor AVF maturation in uremic hemodialysis patients was 0.725,0.763 and 0.822 respectively,and the AUC of serum Lp-PLA2 and FGF-23 levels combined prediction was the largest Conclusion:The increase of serum Lp-PLA2 and FGF-23 levels in uremic hemodialysis patients were independently relate to the poor maturation of AVF,the combination of serum Lp-PLA2 and FGF-23 levels had a good predictive effect on the poor maturation of AVF.
万方数据
维普
