Effects of Etomidate Combined with Dexmedetomidine on Cerebral Glucose and Oxygen Metabolism and Oxidative Stress in Patients with Hypertensive Basal Ganglia Intracerebral Hemorrhage
Objective:To observe the effects of Etomidate combined with dexmedetomidine on cerebral glucose and oxygen metabolism and oxidative stress in patients with hypertensive basal ganglia intracerebral hemorrhage.Methods:90 patients with hyper-tensive basal ganglia cerebral hemorrhage admitted between January 2020 and December 2022 were randomly divided into a control group and a study group using a random number table method,with 45 patients in each group.The patients in the control group received Etomidate anesthesia,and the patients in the study group received Etomidate combined with dexmedetomidine anesthesia.The hemody-namics[heart rate(HR),Mean arterial pressure(MAP)],glucose and oxygen metabolism indicators[oxygen saturation(SjvO2),cerebral oxygen utilization rate(CEO2),oxygen difference between cerebral artery and cerebral vein(AVDO2)],oxidative stress indicators[Mal-ondialdehyde(MDA)and Superoxide dismutase(SOD)]and adverse reactions were compared between the two groups.Results:The heart rate(HR)and Mean arterial pressure(MAP)in the study group were lower than those in the control group from 5 minutes(T1)to the end of surgery(T4)after anesthesia induction(P＜0.05).At the T4 time point,the oxygen saturation(SjvO2)of the study group was higher than that of the control group,while the cerebral oxygen utilization rate(CEO2)and the oxygen difference between cerebral arter-ies and veins(AVDO2)were lower than those of the control group(P＜0.05).At T4 time point,Superoxide dismutase(SOD)in the study group was higher than that in the control group,and Malondialdehyde(MDA)was lower than that in the control group(P＜0.05).There was no difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Etomidate combined with dexmedetomidine in the treatment of hypertensive basal ganglia intracerebral hemorrhage can better maintain body hemodynamics,im-prove cerebral glucose and oxygen metabolism,reduce oxidative stress,and play a good anesthetic effect.
EtomidateDexmetomidineHypertensive basal ganglia cerebral hemorrhageBrain glucose and oxygen metabolismOxidative stress
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维普
