Effects of Etomidate Combined with Dexmedetomidine on Cerebral Glucose and Oxygen Metabolism and Oxidative Stress in Patients with Hypertensive Basal Ganglia Intracerebral Hemorrhage
Effects of Etomidate Combined with Dexmedetomidine on Cerebral Glucose and Oxygen Metabolism and Oxidative Stress in Patients with Hypertensive Basal Ganglia Intracerebral Hemorrhage
Objective:To observe the effects of Etomidate combined with dexmedetomidine on cerebral glucose and oxygen metabolism and oxidative stress in patients with hypertensive basal ganglia intracerebral hemorrhage.Methods:90 patients with hyper-tensive basal ganglia cerebral hemorrhage admitted between January 2020 and December 2022 were randomly divided into a control group and a study group using a random number table method,with 45 patients in each group.The patients in the control group received Etomidate anesthesia,and the patients in the study group received Etomidate combined with dexmedetomidine anesthesia.The hemody-namics[heart rate(HR),Mean arterial pressure(MAP)],glucose and oxygen metabolism indicators[oxygen saturation(SjvO2),cerebral oxygen utilization rate(CEO2),oxygen difference between cerebral artery and cerebral vein(AVDO2)],oxidative stress indicators[Mal-ondialdehyde(MDA)and Superoxide dismutase(SOD)]and adverse reactions were compared between the two groups.Results:The heart rate(HR)and Mean arterial pressure(MAP)in the study group were lower than those in the control group from 5 minutes(T1)to the end of surgery(T4)after anesthesia induction(P＜0.05).At the T4 time point,the oxygen saturation(SjvO2)of the study group was higher than that of the control group,while the cerebral oxygen utilization rate(CEO2)and the oxygen difference between cerebral arter-ies and veins(AVDO2)were lower than those of the control group(P＜0.05).At T4 time point,Superoxide dismutase(SOD)in the study group was higher than that in the control group,and Malondialdehyde(MDA)was lower than that in the control group(P＜0.05).There was no difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Etomidate combined with dexmedetomidine in the treatment of hypertensive basal ganglia intracerebral hemorrhage can better maintain body hemodynamics,im-prove cerebral glucose and oxygen metabolism,reduce oxidative stress,and play a good anesthetic effect.
关键词
依托咪酯/右美托咪定/高血压基底节区脑出血/脑糖氧代谢/氧化应激
Key words
Etomidate/Dexmetomidine/Hypertensive basal ganglia cerebral hemorrhage/Brain glucose and oxygen metabolism/Oxidative stress
维普
万方数据