Effect of Different Anti-VEGF Drugs Combined with Vitrectomy on Proliferative Diabetic Retinopathy and Its Effect on Visual Acuity
Objective:To study the effect of different anti-VEGF drugs combined with vitrectomy on proliferative diabetic retinopathy(PDR)and its effect on visual acuity.Methods:A total of 268 patients with PDR admitted to Gansu Provincial People's Hos-pital from April 2016 to June 2022 were randomly divided into ranibizumab group(88 cases),conbercept group(90 cases)and afliber-cept group(90 cases).The ranibizumab group was treated with ranibizumab injection combined with vitrectomy,the conbercept group was treated with conbercept injection combined with vitrectomy,and the aflibercept group was treated with aflibercept combined with vitrectomy.The clinical effects of the three groups were observed.The levels of vascular endothelial growth factor(VEGF),erythropoi-etin(EPO),best corrected visual acuity(BCVA),central macular thickness(CMT)and intraocular pressure(IOP)were measured before operation,7 days and 28 days after operation.Results:There was no difference in the total effective rate among the three groups(P＞0.05).After 7 days of treatment,the levels of VEGF and EPO in the conbercept group and the aflibercept group were significantly lower than those in the ranibizumab group(P＜0.05).The BCVA level in the conbercept group and the ranibizumab group was signifiicantly lower than that in the aflibercept group after 7 days of treatment.The level of CMT in the conbercept group and the aflibercept group was lower than that in the ranibizumab group after 7 days of treatment(P＜0.05).There was no significant difference in intraocular pressure between the three groups before treatment,7 days after treatment and 28 days after treatment(P＞0.05).Conclusion:Ranibizumab,conbercept and aflibercept combined with vitrectomy have significant therapeutic effects in the treatment of PDR,but conbercept and aflibercept are more effective in reducing macular thickness,while ranibizumab and conbercept are more effective in improving visual acuity.
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