Correlation between Serum β2-microglobulin and Creatinine(Scr)Levels and Risk of Cardiovascular Disease in Patients with Systemic Lupus Erythematosus with Long Disease Course and Low Disease Activity
Objective:To investigate the correlation between serum β2-microglobulin and creatinine expression levels and cardio-vascular disease risk in patients with systemic lupus erythematosus with long disease course and low disease activity.Methods:A total of 100 patients with systemic lupus erythematosus with long disease course and low disease activity who were hospitalized in the rheuma-tology and immunology department of our hospital from March 2017 to December 2022 were retrospectively collected as the study group,and healthy subjects in the same period were included as the negative control group.Study groups were divided into high risk and low risk groups using Framingham score.Serum expression levels of serum β2-microglobulin(β2-microglobulin,β2-MG)and creatinine(Scr)were determined by enzyme-related immunosorbent assay.The risk factors of cardiovascular disease in patients with systemic lupus erythematosus with long disease course and low disease activity were analyzed by logistics regression model,and the correlation betweenβ2-MG,Scr level and Framingham score was analyzed by Pearson test.Results:Serum β2-MG and Scr expression levels were signifi-cantly increased in patients with systemic lupus erythematosus with low disease activity(P＜0.05).Serum β2-MG and Scr expression lev-els in patients with high risk of cardiovascular disease and long course of low disease activity were significantly increased in patients with systemic lupus erythematosus(P＜0.05).The expression levels of β2-MG and Scr were significantly different in patients with different prognosis(P＜0.05).The expression levels of β2-MG and Scr in patients with good prognosis were significantly lower than that in patients with poor prognosis.The better the prognosis,the lower the expression levels of β2-MG and Scr.The proportion of metabolic syndrome and the expression levels of cholesterol and triglyceride in high-risk group were higher than that in low-risk group(P＜0.05).Framingham score,β2-MG and Scr are risk factors for cardiovascular disease in patients with systemic lupus erythematosus with long course and low disease activity.The expression levels of β2-MG and Scr in patients with long disease course and low disease activity were positively correlated with Framingham score.Conclusion:Serum β2-MG and Scr expression levels are positively correlated with the risk of cardio-vascular disease in patients with long disease course and low disease activity.
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维普
