Correlation Analysis of Carotid Ultrasound Features,Bilirubin Lipid Index and Plaque Stability in Elderly Patients with Coronary Heart Disease
Objective:To investigate the correlation between carotid ultrasound features,bilirubin lipid composite index and plaque stability in elderly patients with coronary heart disease.Methods:120 patients with coronary heart disease were selected from Jan-uary 2021 to December 2022.The levels of TC,LDL-C,HDL-C,TBIL,carboxy-terminal propeptide of serum type Ⅰ procollagen,cathep-sin K,matrix metalloproteinase-1 and matrix metalloproteinase-9 were detected in all patients.Carotid artery ultrasound was performed to determine carotid intima-media thickness,and coronary angiography was performed at the same time.The number of coronary artery disease and coronary artery disease score were determined.Carotid block number,ultrasonic blood flow parameters and biochemical in-dexes of common carotid artery were analyzed in different coronary artery disease groups,biochemical indexes of patients with different carotid intima-media thickness and biochemical indexes of patients with different coronary artery disease scores were analyzed.The cor-relation of carotid ultrasound features,bilirubin lipid index and serum plaque stability index in 120 patients with coronary heart disease was analyzed.Results:The levels of carotid intima-media thickness,Gokmen score,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL),car-boxy-terminal propeptide,cathepsin K,matrix metalloproteinase-1 and matrix metalloproteinase-9 in the three-vessel disease group were higher than those in the single-vessel and double-vessel disease groups.The above indexes in the double-branch disease group were high-er than those in the single-branch disease group(P＜0.05),and the TBIL in the single-branch disease group was higher than that in the dou-ble-branch disease group and the triple-branch disease group(P＜0.05),while there were no significance between the double-branch dis-ease group and the triple-branch disease group(P＞0.05).The levels of TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL),carboxy-terminal propeptide of type Ⅰ procollagen,cathepsin K,matrix metalloproteinase-1 and matrix metalloproteinase-9 in the normal intima group were higher than those in the intima thickening and plaque formation groups.The above indexes in the intima thickening group were higher than those in the plaque formation group(P＜0.05),and the TBIL in the normal intima group was higher than that in the intima thickening group and the plaque formation group(P＜0.05),but there was no significance between the intima thickening group and the plaque formation group(P＞0.05).The levels of TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL),carboxy-terminal propeptide of type Ⅰ pro-collagen,cathepsin K,matrix metalloproteinase-1 and matrix metalloproteinase-9 in group with coronary artery disease score ≤ 5 were higher than those in group 6-10 and group 11-15.The above indexes in group 6-10 were higher than those in group 11-15(P＜0.05),and the TBIL in group ≤5 was higher than that in group 6-10 and group 11-15(P＜0.05),but there was no statistical significance between group 6-10 and group 11-15(P＞0.05).There was no difference in the levels of TC,LDL-C and HDL-C among different groups(P＞0.05).Carotid intima-media thickness and Gokmen score were positively correlated with the levels of TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL),carboxy-terminal propeptide of type Ⅰ procollagen,cathepsin K,matrix metalloproteinase-1 and matrix metallopro-teinase-9(P＜0.05).Carotid intima-media thickness and Gokmen score had no correlation with TC,LDL-C,HDL-C and TBIL levels(P＞0.05).Conclusion:The more severe the coronary artery lesions in elderly patients with coronary heart disease,the carotid ultrasound characteristics,bilirubin lipid index and plaque stability continue to deteriorate,and the carotid ultrasound characteristics are positively correlated with the levels of bilirubin lipid index and plaque stability index.
万方数据
维普
