Predictive Value of Three-Dimensional Energy Doppler Ultrasound Combined with Serum HE4,TK1 and YKL-40 for Endometrial Cancer in Postmenopausal Bleeding Patients
Objective:To study the predictive value of three-dimensional energy Doppler ultrasound combined with serum human epididymal protein 4(HE4),thymidine kinase 1(TK1)and chitinase protein 40(YKL-40)for endometrial cancer in postmenopausal bleeding patients.Methods:150 postmenopausal bleeding patients who were admitted from October 2019 to October 2022 in the our hospital were selected.They were divided into endometrial carcinoma group(31 cases)and endometrial benign hyperplasia group(119 cases)according to the difference of pathological examination results.Three-dimensional energy Doppler ultrasound was performed in all patients,and serum HE4,TK1,YKL-40 levels were detected.The efficacy of three-dimensional energy Doppler ultrasound combined with serum HE4,TK1,and YKL-40 levels in predicting endometrial cancer in postmenopausal bleeding patients was analyzed by receiver operating characteristic curve(ROC).Results:Blood flow index(FI),angiogenesis index(VI),angiogenesis-blood flow index(VFI)and the composite index I constructed by these three parametersin endometrial cancer group were higher than those in endometrial be-nign hyperplasia group(all P＜0.05).The serum levels of HE4,TK1 and YKL-40 in endometrial cancer group were higher than those in endometrial benign hyperplasia group(all P＜0.05).Through ROC curve analysis found that the area under the curve(AUC),sensitivity,specificity and Yoden index of three-dimensional energy Doppler ultrasound combined with serum HE4,TK1 and YKL-40 levels in pre-dicting endometrial cancer in postmenopausal bleeding patients were higher than those of the four independent predictions.Conclusion:Three-dimensional energy Doppler ultrasound combined with serum HE4,TK1 and YKL-40 levels were more effective in predicting endometrial cancer in postmenopausal bleeding patients.
Three-dimensional energy Doppler ultrasoundHE4TK1YKL-40Postmenopausal bleedingEndometrial cancerPre-dictive value
万方数据
维普
