Effects of Tongzhi Surunjiang Capsules Combined with Celecoxib on Serum Inflammatory Factors and Pain Mediators in Patients with Early Knee Osteoarthritis
Objective:To observe the effects of Tongzhi surunjiang capsules combined with celecoxib on serum inflammatory fac-tors and pain mediators in patients with early knee osteoarthritis(KOA).Methods:80 patients with early KOA who were admitted to Shi-jiazhuang People's Hospital from June 2021 to December 2022 were selected,and patients were divided into control group(celecoxib,40 cases)and observation group(tongzhi surunjiang capsules combined with celecoxib,40 cases)by random number table method.The effi-cacy,pain visual analogue scale(VAS),Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,inflammatory factors and pain mediators were compared between two groups.Results:The total effective rate in observation group was higher than that in control group(P＜0.05).1 month after treatment,the VAS and WOMAC scores in two groups decreased,and those in observation group were lower than control group at the same time point(P＜0.05).1 month after treatment,the levels of tumor necrosis factor-α(TNF-α),in-terleukin-1β(IL-1β)and interleukin-6(IL-6)in two groups decreased,and those in observation group were lower than control group at the same time point(P＜0.05).1 month after treatment,prostaglandin E2(PGE2)and substance P(SP)decreased in two groups,and those in observation group were lower than control group at the same time point(P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:The combination of celecoxib and tongzhi surunjiang capsule in the treat-ment of early KOA patients can relieve pain,improve the clinical treatment effect,improve joint function,and also improve the levels of serum inflammatory factors and pain mediators.
Tong zhi su run capsulesCelecoxibEarly knee osteoarthritisInflammatory factorsPain mediator
万方数据
维普
