Influence of Central Precocious Puberty on Growth and Development of Children and Analysis of Risk Factors
Objective:To analyze the effects of central precocious puberty on the growth and development of children and its risk factors.Methods:105 children with central precocious puberty admitted to our hospital from January 2020 to January 2023 were selected as the observation group,and 105 children with normal development in the same period were selected as the control group.Growth and development indicators,serum insulin-like growth factor(IGF-1)and insulin-like growth factor binding protein 3(IGF-BP3)expression levels were compared between the two groups.The dietary pattern,living conditions and family status of the participants were investigated by questionnaire.Univariate analysis and multivariate Logistic regression analysis were used.Results:The height,weight,body mass in-dex and bone age of observation group were higher than those of control group(P＜0.05).The expression levels of serum IGF-1 and IGF-BP3 in observation group were higher than those in control group(P＜0.05).After univariate analysis,napping habits,exercise time,sleep with light on,schoolwork load,frequent use of plastic products,adult toiletries and skin care products,watching emotional TV,ma-temal education,occupation,age of menstruating,parental relationship,companionship,balanced diet pattern and high-calorie and high-fat diet pattern were all associated with central precocious puberty(P＜0.05).Multivariate Logistic regression analysis showed that balanced dietary pattern,napping habit,and long exercise time were all protective factors for central precocious puberty(P＜0.05),while high-calorie and high-fat dietary pattern,young age of mother at menarche,disharmonious relationship between parents,and little parental companionship were all risk factors for central precocious puberty(P＜0.05).Conclusion:Central precocious puberty can affect the growth and development progress of children and is closely related to high-calorie and high-fat dietary patterns,maternal age at menarche,parental relationship and companionship.Family relationships should be improved and children should be helped to develop good habits of balanced meals,naps and exercise that are beneficial to normal growth and development.
ChildrenCentral precocious pubertyGrowth and developmentRisk factorsProtective factor
万方数据
维普
