Correlation between the Expression Levels of IL-17,IL-21 and IL-22 in Serum and Placenta of Preterm Mothers and Neonatal Infection
Objective:To analyze the correlation between the expression levels of IL-17,IL-21 and IL-22 in serum and placenta of preterm pregnant women and neonatal infection.Methods:120 preterm parturients who delivered in our hospital from July 2020 to De-cember 2021 were selected as the observation group,and 120 full-term parturients in the same period were selected as the control group.The expression levels of IL-17,IL-21 and IL-22 in serum and placenta of mothers in the two groups were detected.According to whether newborns delivered by mothers in the observation group were infected or not,they were divided into infected group and non-infected group.The expression levels of IL-17,IL-21 and IL-22 in serum and placenta of mothers in the two groups were compared.Multivariate Logistic regression analysis and receiver operating characteristic curve(ROC)were used to analyze the relationship between serum and placental IL-17,IL-21 and IL-22 and neonatal infection.Results:The expression levels of IL-17,IL-21 and IL-22 in serum and placenta of observation group were higher than those of control group(P＜0.05).The expression levels of IL-17,IL-21 and IL-22 in serum and pla-centa of infected group were higher than those of non-infected group(P＜0.05).Multivariate Logistic regression analysis showed that serum and placental IL-17,IL-21 and IL-22 were independent predictors of neonatal infection(P＜0.05).According to Pearson correlation analysis,there were positive correlations between serum IL-17 and placental IL-17 mRNA,serum IL-21 and placental IL-21 mRNA,and serum IL-22 and placental IL-22 mRNA in preterm parturients(P＜0.05).According to ROC curve analysis,the AUC of serum IL-17 and IL-21 combined with IL-22 for predicting neonatal infection was 0.910.Conclusion:The elevated levels of IL-17,IL-21 and IL-22 in serum and placenta of preterm parturients are closely related to the occurrence of neonatal infection,and the efficacy of serum IL-17,IL-21 and IL-22 combined with IL-22 in predicting neonatal infection is higher,which is worthy of further study and application.
万方数据
维普
