Effects of Wuling Capsule Combined with Tenofovir Disoproxil Fumarate Tablets on Oxidative Stress,CD4+CD25+Regulatory T Cells and Serum MMP-1,MMP-2 and TIMP-1 in Patients with Chronic Hepatitis B
Objective:To investigate the effects of wuling capsules combine with tenofovir disoproxil fumarate tablets on oxida-tive stress,CD4+CD25+regulatory T cells,serum matrix metalloproteinase-1(MMP-1),matrix metalloproteinase-2(MMP-2)and tissue inhibitor of metalloproteinase-1(TIMP-1)in patients with chronic hepatitis B(CHB).Methods:122 CHB patients who were admitted to the Infectious Diseases Hospital Affiliated to Soochow University from June 2021 to December 2022 were enrolled,patients were divided into control group(n=61,tenofovir disoproxil fumarate tablets)and study group(n=61,wuling capsules combined with tenofovir diso-proxil fumarate tablets)by random number table method.The efficacy,oxidative stress indexes,CD4+CD25+ regulatory T cells,liver function indexes[total bilirubin(TBIL),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT)],serum MMP-1,MMP-2,TIMP-1 levels and adverse reactions were compared between two groups.Results:The total clinical effective rate in study group was higher than that in control group(P＜0.05).The malondialdehyde(MDA)decreased in two groups after treatment,and study group was lower than that of control group at the same time point.Superoxide dismutase(SOD)increased,and study group was higher than that of control group at the same time point(P＜0.05).CD4+CD25+regulatory T cells decreased in two groups after treatment,and study group was lower than that of control group at the same time point(P＜0.05).MMP-1,MMP-2 and TIMP-1 decreased in two groups after treat-ment,and study group was lower than that of control group at the same time point(P＜0.05).TBIL,ALT and GGT decreased in two groups after treatment,and study group was lower than that of control group at the same time point(P＜0.05).There was no difference in the total incidence of adverse reactions between two groups(P＞0.05).Conclusion:Wuling capsule combine with tenofovir disoproxil fu-marate tablets in the treatment of CHB patients,which can effectively reduce the body's oxidative stress,regulate CD4+CD25+ regulatory T cells and serum MMP-1,MMP-2,TIMP-1 levels.
Wuling capsuleTenofovir disoproxil fumarate tabletsChronic hepatitis BOxidative stressCD4+CD25+regulatory T cellsMMP-1MMP-2TIMP-1
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